HCSGD entry for FOXO1
1. General information
| Official gene symbol | FOXO1 |
|---|---|
| Entrez ID | 2308 |
| Gene full name | forkhead box O1 |
| Other gene symbols | FKH1 FKHR FOXO1A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001078 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | IEA | molecular_function |
| GO:0001568 | Blood vessel development | IBA | biological_process |
| GO:0001659 | Temperature homeostasis | ISS | biological_process |
| GO:0001678 | Cellular glucose homeostasis | ISS | biological_process |
| GO:0003682 | Chromatin binding | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | ISS | cellular_component |
| GO:0005829 | Cytosol | ISS TAS | cellular_component |
| GO:0006473 | Protein acetylation | ISS | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | ISS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007389 | Pattern specification process | IBA | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | ISS | biological_process |
| GO:0008301 | DNA binding, bending | IBA | molecular_function |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0009267 | Cellular response to starvation | ISS | biological_process |
| GO:0009790 | Embryo development | IBA | biological_process |
| GO:0009888 | Tissue development | IBA | biological_process |
| GO:0031018 | Endocrine pancreas development | TAS | biological_process |
| GO:0032873 | Negative regulation of stress-activated MAPK cascade | IDA | biological_process |
| GO:0034599 | Cellular response to oxidative stress | ISS | biological_process |
| GO:0035947 | Regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0042127 | Regulation of cell proliferation | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IDA | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045444 | Fat cell differentiation | ISS | biological_process |
| GO:0045599 | Negative regulation of fat cell differentiation | ISS | biological_process |
| GO:0045722 | Positive regulation of gluconeogenesis | IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0051721 | Protein phosphatase 2A binding | ISS | molecular_function |
| GO:0070417 | Cellular response to cold | ISS | biological_process |
| GO:0071732 | Cellular response to nitric oxide | ISS | biological_process |
| GO:2000505 | Regulation of energy homeostasis | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1265357129 | 0.8074573458 | 0.7252932274 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0530427881 |
| GSE13712_SHEAR | Down | -0.4587874343 |
| GSE13712_STATIC | Down | -0.7298608924 |
| GSE19018 | Up | 0.0210620186 |
| GSE19899_A1 | Up | 0.0420648527 |
| GSE19899_A2 | Up | 0.1221556331 |
| PubMed_21979375_A1 | Up | 0.8089792088 |
| PubMed_21979375_A2 | Up | 0.2776812866 |
| GSE35957 | Up | 0.2464825765 |
| GSE36640 | Up | 0.1823007243 |
| GSE54402 | Up | 0.6915513464 |
| GSE9593 | Down | -0.0185254732 |
| GSE43922 | Up | 0.0406453944 |
| GSE24585 | Up | 0.2456792337 |
| GSE37065 | Up | 0.2059051225 |
| GSE28863_A1 | Up | 0.0868392139 |
| GSE28863_A2 | Up | 0.0024904250 |
| GSE28863_A3 | Up | 0.3059796376 |
| GSE28863_A4 | Up | 0.0506140047 |
| GSE48662 | Down | -0.0308276960 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-182-5p | MIMAT0000259 | MIRT001086 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19574223 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT001087 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19574223 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT001087 | Immunohistochemistry//Northern blot//qRT-PCR//Western blot | Functional MTI | 20028871 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT001088 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19574223 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT001088 | Immunohistochemistry//Northern blot//qRT-PCR//Western blot | Functional MTI | 20028871 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT001088 | Immunohistochemistry//qRT-PCR//Western blot | Functional MTI | 22213032 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT003300 | Immunohistochemistry//Northern blot//qRT-PCR//Western blot | Functional MTI | 20028871 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT003300 | Luciferase reporter assay | Functional MTI | 23509296 |
| hsa-miR-153-3p | MIMAT0000439 | MIRT003299 | Immunohistochemistry//Northern blot//qRT-PCR//Western blot | Functional MTI | 20028871 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT003298 | Immunohistochemistry//Northern blot//qRT-PCR//Western blot | Functional MTI | 20028871 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT003297 | Immunohistochemistry//Northern blot//qRT-PCR//Western blot | Functional MTI | 20028871 |
| hsa-miR-223-3p | MIMAT0000280 | MIRT006733 | Flow//Immunocytochemistry//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22569260 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT016933 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027447 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-106b-3p | MIMAT0004672 | MIRT038575 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT045840 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048219 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT051345 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-9-5p | MIMAT0000441 | NA | hsa-miR-9 | {Western blot} | {overexpression by miRNA mimics tranfection} | 20028871 | |
| hsa-miR-27a-3p | MIMAT0000084 | NA | hsa-miR-27a | {Western blot} | {overexpression by miRNA mimics tranfection} | 20028871 | |
| hsa-miR-96-5p | MIMAT0000095 | NA | hsa-miR-96 | {Western blot} | {overexpression by miRNA mimics tranfection} | 20028871 | |
| hsa-miR-183-5p | MIMAT0000261 | NA | hsa-miR-183 | {Western blot} | {overexpression by miRNA mimics tranfection} | 20028871 | |
| hsa-miR-186-5p | MIMAT0000456 | NA | hsa-miR-186 | {Western blot} | {overexpression by miRNA mimics tranfection} | 20028871 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 18 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27349869 | As a result, FoxO1 and FoxO3 transcription activity was recovered |
| 27206970 | The effects on VSMCs senescence and collagen synthesis were mediated by restoration of angiotensin II-induced downregulation of Gas6 and Axl expression and a subsequent reduction of Akt and FoxO1a phosphorylation |
| 27206970 | Furthermore, when FoxO1a expression was silenced by using a specific siRNA, the inhibitory effect of testosterone on MMP-2 activity was revered as well, that indicated this process was Akt/FoxO1a dependence |
| 26763397 | Our results showed that arsenic induced the nuclear translocation of FOXO1 and FOXO3a, and altered the cell cycle, with cells accumulating at the G2/M phase |
| 26577046 | Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming |
| 26577046 | Overexpression of constitutively active FOXO1 in PR-A-expressing cells conferred robust ligand-dependent upregulation of the PR-B target genes GZMA, IGFBP1, and p21, and induced cellular senescence |
| 26577046 | In the presence of endogenous active FOXO1, PR-A was phosphorylated on Ser294 and transactivated PR-B at PR-B target genes; these events were blocked by the FOXO1 inhibitor (AS1842856) |
| 26577046 | PR isoform-specific regulation of the FOXO1/p21 axis recapitulated in human primary ovarian tumor explants treated with progestin; loss of progestin sensitivity correlated with high AKT activity |
| 26577046 | IMPLICATIONS: This study indicates FOXO1 as a critical component for progesterone signaling to promote cellular senescence and reveals a novel mechanism for transcription factor control of hormone sensitivity |
| 26469953 | The mechanism involves not only the inhibition of autophagy early induced by these stimuli in the pathway to senescence, but also the increase in levels and nuclear localization of both the cell cycle suppressors p53/p21 and the longevity promoters FOXO1A, FOXO3A and SIRT1 |
| 26390028 | Moreover, silencing miR-195 in OMSCs by transfection of miR-195 inhibitor significantly restored antiaging factors expression including Tert and Sirt1 as well as phosphorylation of Akt and FOXO1 |
| 25839657 | Intracellular ROS levels were increased in hBM-MSCs; this was accompanied by a decrease in the expression of the antioxidant enzymes catalase and superoxide dismutase (SOD)1 and 2 and of phosphorylated forkhead box O1 (p-FOXO1) as well as an increase in the expression of p53 and p16, along with a reduction in differentiation potential |
| 25662949 | The protein expressions for FoxO1 and FoxO3 were increased in OLETF-AL rats, but the levels of phosphorylated (p)-Akt were decreased compared to those in OLETF-CR rats |
| 25263463 | Signalling impairment distal to Akt in phosphorylation of AS160 and FoxO1 was evident in senescent HepG2 cells |
| 25263463 | Persistent nuclear localisation of FoxO1 was demonstrated in senescent cells despite insulin stimulation |
| 25186470 | METHODS: Small interfering RNAs (siRNAs) targeting FOXO1 (siFOXO1) and FOXO3 (siFOXO3) were transfected into human articular chondrocytes |
| 25186470 | Knockdown of FOXO1 and FOXO1+3 resulted in significant reductions in levels of glutathione peroxidase 1 (GPX-1), catalase, light chain 3 (LC3), Beclin1, and sirtuin 1 (SIRT-1) proteins following treatment with tBHP |
| 24269635 | RESULTS: Human cartilage expressed FOXO1 and FOXO3 but not FOXO4 proteins |
| 24269635 | FOXO1 and FOXO3 were more strongly expressed the superficial and mid zone as compared to the deep zone and were mainly localized in nuclei |
| 24269635 | During human joint aging, expression of FOXO1 and FOXO3 was markedly reduced in the superficial zone of cartilage regions exposed to maximal weight bearing |
| 24269635 | In cultured chondrocytes, IL-1beta and TNF-alpha suppressed FOXO1, while TGF-beta and PDGF increased FOXO1 and FOXO3 expression |
| 24269635 | FOXO1 and FOXO3 phosphorylation was increased by IL-1beta, PDGF, bFGF, IGF-1, and the oxidant t-BHP |
| 23708447 | Progesterone and FOXO1 signaling: harnessing cellular senescence for the treatment of ovarian cancer |
| 23574718 | Progestin (R5020) stimulation of ES-2 cells stably expressing GFP-PR induced cellular senescence characterized by altered cellular morphology, prolonged survival, senescence-associated beta-galactosidase activity, G1 cell cycle arrest and upregulation of the cell cycle inhibitor, p21, as well as the Forkhead-box transcription factor, FOXO1; these results repeated in unmodified ER+/PR+ PEO4 OC cells |
| 23574718 | PR-B and FOXO1 were detected within the same PRE-containing regions of the p21 upstream promoter |
| 23574718 | Inhibition of FOXO1 (with AS1842856) or stable FOXO1 knockdown inhibited progestin-induced p21 expression and blocked progestin-induced senescence |
| 23494737 | We have demonstrated that SIRT3 interacts with forkhead box protein O1 (FOXO1) |
| 23494737 | High glucose levels also increased aging phenotypes and FOXO1 acetylation level |
| 23494737 | We have demonstrated that overexpression of SIRT3 under high glucose conditions reduces FOXO1 acetylation, suggesting that deacetylation of FOXO1 by SIRT3 elevates the expression of the FOXO1 target genes, catalase, and manganese superoxide dismutase (MnSOD) while decreasing senescence phenotypes |
| 23494737 | The data showed that shRNA-SIRT3 accelerated senescence phenotypes and acetylation of FOXO1; the expression level of catalase and MnSOD decreased compared with the control group |
| 21251764 | Milk signalling down-regulates the key transcription factor FoxO1 leading to up-regulation of insulin promoter factor-1 which stimulates beta-cell proliferation, insulin secretion as well as coexpression of islet amyloid polypeptide (IAPP) |
| 20424141 | Finally, overexpression of miR-34a increased the level of Sirt1 effector-acetylated forkhead box O transcription factors 1 (FoxO1), an effect mimicked in EPCs following Sirt1 knockdown |
| 19786632 | In young human umbilical vein endothelial cells, human aortic endothelial cells, and human coronary artery endothelial cells, miR-217 induces a premature senescence-like phenotype and leads to an impairment in angiogenesis via inhibition of SirT1 and modulation of FoxO1 (forkhead box O1) and endothelial nitric oxide synthase acetylation |
| 15741276 | The FOXO family of forkhead transcription factors, FOXO1, FOXO3a, and FOXO4, play a critical role in this signal transduction pathway |
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