HCSGD entry for NCOA6
1. General information
| Official gene symbol | NCOA6 |
|---|---|
| Entrez ID | 23054 |
| Gene full name | nuclear receptor coactivator 6 |
| Other gene symbols | AIB3 ASC2 NRC PRIP RAP250 TRBP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003682 | Chromatin binding | ISS | molecular_function |
| GO:0003713 | Transcription coactivator activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA NAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005667 | Transcription factor complex | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006260 | DNA replication | NAS | biological_process |
| GO:0006281 | DNA repair | NAS | biological_process |
| GO:0006310 | DNA recombination | NAS | biological_process |
| GO:0006352 | DNA-templated transcription, initiation | IDA | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | ISS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0007420 | Brain development | ISS | biological_process |
| GO:0007507 | Heart development | ISS | biological_process |
| GO:0009725 | Response to hormone | TAS | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030099 | Myeloid cell differentiation | IDA | biological_process |
| GO:0030331 | Estrogen receptor binding | TAS | molecular_function |
| GO:0030374 | Ligand-dependent nuclear receptor transcription coactivator activity | IPI | molecular_function |
| GO:0030520 | Intracellular estrogen receptor signaling pathway | NAS | biological_process |
| GO:0035097 | Histone methyltransferase complex | IDA | cellular_component |
| GO:0042921 | Glucocorticoid receptor signaling pathway | NAS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046965 | Retinoid X receptor binding | TAS | molecular_function |
| GO:0046966 | Thyroid hormone receptor binding | IDA | molecular_function |
| GO:0060716 | Labyrinthine layer blood vessel development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6317685574 | 0.5021569393 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1298855926 |
| GSE13712_SHEAR | Up | 0.0864724993 |
| GSE13712_STATIC | Down | -0.0872102259 |
| GSE19018 | Down | -0.1213395944 |
| GSE19899_A1 | Down | -0.0763671271 |
| GSE19899_A2 | Down | -0.1099712542 |
| PubMed_21979375_A1 | Down | -0.0727764922 |
| PubMed_21979375_A2 | Down | -0.1522088816 |
| GSE35957 | Down | -0.1063573912 |
| GSE36640 | Down | -0.4599247429 |
| GSE54402 | Down | -0.0763010902 |
| GSE9593 | Up | 0.2473252251 |
| GSE43922 | Up | 0.0112171448 |
| GSE24585 | Down | -0.1051539676 |
| GSE37065 | Down | -0.0260661825 |
| GSE28863_A1 | Up | 0.6517284938 |
| GSE28863_A2 | Up | 0.3797041401 |
| GSE28863_A3 | Up | 0.0351764610 |
| GSE28863_A4 | Up | 0.0379362073 |
| GSE48662 | Down | -0.1485792558 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-224-5p | MIMAT0000281 | MIRT003235 | Luciferase reporter assay | Non-Functional MTI | 20065103 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT023418 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028192 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT031325 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-760 | MIMAT0004957 | MIRT036743 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044079 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
