HCSGD entry for WDTC1

1. General information

Official gene symbolWDTC1
Entrez ID23038
Gene full nameWD and tetratricopeptide repeats 1
Other gene symbolsADP DCAF9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0004857Enzyme inhibitor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006006Glucose metabolic processIEAbiological_process
GO:0008361Regulation of cell sizeIEAbiological_process
GO:0016567Protein ubiquitinationIEAbiological_process
GO:0032869Cellular response to insulin stimulusIEAbiological_process
GO:0035264Multicellular organism growthIEAbiological_process
GO:0042393Histone bindingIEAmolecular_function
GO:0042826Histone deacetylase bindingIEAmolecular_function
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0045717Negative regulation of fatty acid biosynthetic processIEAbiological_process
GO:0055082Cellular chemical homeostasisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18577465140.66943199350.84182919461.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0507828657
GSE13712_SHEARDown-0.1239586945
GSE13712_STATICUp0.0795914648
GSE19018Up0.1221715180
GSE19899_A1Down-0.0320863176
GSE19899_A2Up0.3769184186
PubMed_21979375_A1Up0.6517448084
PubMed_21979375_A2Up0.5289919903
GSE35957Up0.1814401735
GSE36640Up0.2165682101
GSE54402Down-0.0495586365
GSE9593Up0.0664509243
GSE43922Up0.0141759024
GSE24585Up0.1859175823
GSE37065Down-0.2406575234
GSE28863_A1Up0.3104008329
GSE28863_A2Up0.4154986217
GSE28863_A3Down-0.2519711671
GSE28863_A4Down-0.4886018412
GSE48662Up0.3444596488

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148a-3pMIMAT0000243MIRT048038CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 9 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27168476Using cell counting, colorimetric, and fluorimetric analyses, immunoenzymatic assays, and real time PCR experiments, NSC culture proliferation, senescence, reactive oxygen species, and ADP/ATP levels were assessed
26865365ATP hydrolysis and adenosine diphosphate (ADP)/ATP exchange are key events for substrate binding and Hsp70 release during folding of nascent polypeptides
244737731 binds with high affinity O-acetyl ADP ribose, a small metabolite produced by the reaction catalysed by NAD+-dependent deacetylase SIRT1, whereas macroH2A1
17982416Agonists of P2Y1 (ADP) and P2Y2/P2Y4 (ATP, UTP) receptors at 10 microM or 100 microM concentrations were added to the bathing medium
1798241612 (n=3) for 10 microM ADP, 2
1798241633 (n=6) for 100 microM ADP, 1
17982416Cells at passage 18 showed significantly lower levels of intracellular calcium induced by ATP (36%), UTP (34%), and ADP (52%) compared to cells at passage 2, independent from any changes in P2Y receptor changes in expression
12531250Respiratory control index (RCI), ADP/O ratio, State 3 respiration and dinitrophenol (DNP)-dependent uncoupled respiration were significantly lower in SAMP8 than in SAMR1
12531250Melatonin administration (10mg/kg body weight, intraperitoneally) 1h prior to sacrifice significantly increased RCI, ADP/O ratio, State 3 respiration and DNP-induced uncoupled respiration in SAMP8 while also significantly reducing State 4 respiration in SAMP8
9762523Identification of altered expression of ADP/ATP translocase during cellular senescence in vitro
9762523Through DNA sequencing, one of these differentially displayed mRNAs was identified as mitochondrial ADP/ATP translocase
9762523The altered expression of ADP/ATP translocase in different stages of senescent fibroblasts was further confirmed by Northern blots and semiquantitative RT-PCR
9762523Our results demonstrate that expression of ADP/ATP translocase is progressively decreased during the process of in vitro cellular senescence
9762523Further analyses with MTT assays indicate that the decreased expression of ADP/ATP translocase in senescent cells is in parallel with the decline of mitochondrial functions, suggesting that altered expression of this important mitochondrial enzyme might play an active role in the process of cellular senescence
8903398The change in the rate of gluconeogenesis was not accompanied by changes in any of the following parameters: phosphoenolpyruvate carboxykinase or pyruvate carboxylase activities or mitochondrial ATP/ADP or cytosolic NADH/NAD+ ratios
3613687In this paper we have used a new method which allows the simultaneous extraction and HPLC determination of ATP, ADP, AMP, NADP, NADPH, NAD and NADH to evaluate the changes in concentration of these compounds during maturation of rabbit reticulocytes and cell aging
3613687The results show a significant increase of ATP concentration, higher ATP/ADP, ATP/AMP ratios and lower NADP+/NADPH, NAD+/NADH ratios in rabbit reticulocytes when compared to mature cells
16656887Senescent cells failed to recover from harmful effects of radiation on: 1) mitochondrial yield, 2) in vivo incorporation of amino acids into mitochondrial protein, and 3) mitochondrial respiratory control and ADP/O
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