HCSGD entry for KDM1A

1. General information

Official gene symbolKDM1A
Entrez ID23028
Gene full namelysine (K)-specific demethylase 1A
Other gene symbolsAOF2 BHC110 KDM1 LSD1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMP ISSbiological_process
GO:0000790Nuclear chromatinIDA ISScellular_component
GO:0001085RNA polymerase II transcription factor bindingIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002039P53 bindingIPImolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexISScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0006482Protein demethylationIMPbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008134Transcription factor bindingIDAmolecular_function
GO:0008283Cell proliferationIEAbiological_process
GO:0010725Regulation of primitive erythrocyte differentiationIEAbiological_process
GO:0016491Oxidoreductase activityIDA IEAmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0030374Ligand-dependent nuclear receptor transcription coactivator activityIMPmolecular_function
GO:0030851Granulocyte differentiationIEAbiological_process
GO:0032091Negative regulation of protein bindingIMPbiological_process
GO:0032451Demethylase activityIMPmolecular_function
GO:0032452Histone demethylase activityIDAmolecular_function
GO:0032453Histone demethylase activity (H3-K4 specific)IDAmolecular_function
GO:0032454Histone demethylase activity (H3-K9 specific)IDAmolecular_function
GO:0033169Histone H3-K9 demethylationIDAbiological_process
GO:0034648Histone demethylase activity (H3-dimethyl-K4 specific)IDAmolecular_function
GO:0034720Histone H3-K4 demethylationIDA IEAbiological_process
GO:0043392Negative regulation of DNA bindingICbiological_process
GO:0043426MRF bindingIDAmolecular_function
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDA IMPbiological_process
GO:0043518Negative regulation of DNA damage response, signal transduction by p53 class mediatorIMPbiological_process
GO:0044212Transcription regulatory region DNA bindingISSmolecular_function
GO:0045648Positive regulation of erythrocyte differentiationIEAbiological_process
GO:0045654Positive regulation of megakaryocyte differentiationIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046886Positive regulation of hormone biosynthetic processIEAbiological_process
GO:0050660Flavin adenine dinucleotide bindingIDA IEAmolecular_function
GO:0050681Androgen receptor bindingIDAmolecular_function
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0051572Negative regulation of histone H3-K4 methylationIEAbiological_process
GO:0051573Negative regulation of histone H3-K9 methylationIEAbiological_process
GO:0055001Muscle cell developmentISSbiological_process
GO:1902166Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIMPbiological_process
GO:2000179Positive regulation of neural precursor cell proliferationIEAbiological_process
GO:2000648Positive regulation of stem cell proliferationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.77195011210.07778967360.99999024730.5279100799

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0419726770
GSE13712_SHEARDown-0.0927311732
GSE13712_STATICDown-0.1191519365
GSE19018Up0.1746688258
GSE19899_A1Down-0.2346303073
GSE19899_A2Down-0.0876686621
PubMed_21979375_A1Down-0.0543095696
PubMed_21979375_A2Down-0.0967948173
GSE35957Down-0.7959464664
GSE36640Down-1.0782694936
GSE54402Up0.2558792415
GSE9593Down-0.4838061068
GSE43922Down-0.1281604970
GSE24585Down-0.0242154549
GSE37065Down-0.2521261865
GSE28863_A1Up0.7191257997
GSE28863_A2Up0.7675846936
GSE28863_A3Down-0.4162438181
GSE28863_A4Down-0.2361544507
GSE48662Down-0.0115206847

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-137MIMAT0000429MIRT004579Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI20682795
hsa-miR-137MIMAT0000429MIRT004579Luciferase reporter assayFunctional MTI23400681
hsa-miR-155-5pMIMAT0000646MIRT020665ProteomicsFunctional MTI (Weak)18668040
hsa-miR-500a-5pMIMAT0004773MIRT037998CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046281CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24529708TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres
24529708At uncapped telomeres, LSD1 associates with MRE11, one of the nucleases implicated in the processing of 3' telomeric G overhangs, and we show that LSD1 is required for efficient removal of these structures
24529708Furthermore, LSD1 enhances the nuclease activity of MRE11 in vitro
24529708Our data indicate that recruitment of LSD1 to deprotected telomeres requires MRE11 and is promoted by TERRA
24529708LSD1 stimulates MRE11 catalytic activity and nucleolytic processing of uncapped telomeres
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