HCSGD entry for SPEN
1. General information
| Official gene symbol | SPEN |
|---|---|
| Entrez ID | 23013 |
| Gene full name | spen homolog, transcriptional regulator (Drosophila) |
| Other gene symbols | HIAA0929 MINT RBM15C SHARP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0001085 | RNA polymerase II transcription factor binding | IPI | molecular_function |
| GO:0001191 | RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription | IDA | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003697 | Single-stranded DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0007219 | Notch signaling pathway | IEA | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0017053 | Transcriptional repressor complex | IDA | cellular_component |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0050769 | Positive regulation of neurogenesis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0117747920 | 0.9430269063 | 0.2721021071 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1458144468 |
| GSE13712_SHEAR | Up | 0.5555361116 |
| GSE13712_STATIC | Up | 0.2750539028 |
| GSE19018 | Down | -0.1377125629 |
| GSE19899_A1 | Up | 0.0764094399 |
| GSE19899_A2 | Down | -0.0286841509 |
| PubMed_21979375_A1 | Up | 0.4527013894 |
| PubMed_21979375_A2 | Up | 0.6731751607 |
| GSE35957 | Down | -0.3439191466 |
| GSE36640 | Down | -0.3243397993 |
| GSE54402 | Up | 0.5725604131 |
| GSE9593 | Down | -0.0832126637 |
| GSE43922 | Up | 0.1090815211 |
| GSE24585 | Up | 0.4885187330 |
| GSE37065 | Up | 0.1152847612 |
| GSE28863_A1 | Up | 1.4358839482 |
| GSE28863_A2 | Up | 1.1746558697 |
| GSE28863_A3 | Up | 0.4412777408 |
| GSE28863_A4 | Down | -0.1142794511 |
| GSE48662 | Up | 0.0640972845 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-151a-5p | MIMAT0004697 | MIRT019521 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037187 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-5p | MIMAT0004587 | MIRT038656 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039166 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039949 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041415 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042502 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043099 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043465 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-328-3p | MIMAT0000752 | MIRT043756 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044364 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044789 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045089 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046031 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048159 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049048 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051293 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
