HCSGD entry for KDM2A
1. General information
| Official gene symbol | KDM2A |
|---|---|
| Entrez ID | 22992 |
| Gene full name | lysine (K)-specific demethylase 2A |
| Other gene symbols | CXXC8 FBL11 FBL7 FBXL11 JHDM1A LILINA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000790 | Nuclear chromatin | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0045322 | Unmethylated CpG binding | IEA | molecular_function |
| GO:0051864 | Histone demethylase activity (H3-K36 specific) | IEA | molecular_function |
| GO:0070544 | Histone H3-K36 demethylation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0721002773 | 0.8695792941 | 0.5717840916 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0882806512 |
| GSE13712_SHEAR | Up | 0.1347479447 |
| GSE13712_STATIC | Up | 0.0471281967 |
| GSE19018 | Down | -0.0051370734 |
| GSE19899_A1 | Up | 0.1308015499 |
| GSE19899_A2 | Up | 0.4624530005 |
| PubMed_21979375_A1 | Up | 0.2548047898 |
| PubMed_21979375_A2 | Up | 0.5794749327 |
| GSE35957 | Down | -0.4976957220 |
| GSE36640 | Up | 0.0787248636 |
| GSE54402 | Up | 0.1693892213 |
| GSE9593 | Down | -0.1281590411 |
| GSE43922 | Up | 0.1436592516 |
| GSE24585 | Up | 0.4297008866 |
| GSE37065 | Up | 0.0435846097 |
| GSE28863_A1 | Up | 0.8326925085 |
| GSE28863_A2 | Up | 0.5566442365 |
| GSE28863_A3 | Down | -0.6293003435 |
| GSE28863_A4 | Down | -0.0619420001 |
| GSE48662 | Up | 0.0980743363 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022928 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031826 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036415 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038392 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039165 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040732 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22100412 | The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner |
| 22100412 | Here we show that the histone demethylases Jhdm1a/1b are key effectors of somatic cell reprogramming downstream of vitamin C |
| 22100412 | We then identified Jhdm1a/1b, two known vitamin-C-dependent H3K36 demethylases, as potent regulators of reprogramming through gain- and loss-of-function approaches |
| 18836456 | JmjC domain-containing histone demethylase 1b (Jhdm1b, also known as Kdm2b and Fbxl10), the mammalian paralog of the histone demethylase Jhdm1a (also known as Kdm2a and Fbxl11), has been implicated in cell-cycle regulation and tumorigenesis |
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