HCSGD entry for TPX2
1. General information
| Official gene symbol | TPX2 |
|---|---|
| Entrez ID | 22974 |
| Gene full name | TPX2, microtubule-associated, homolog (Xenopus laevis) |
| Other gene symbols | C20orf1 C20orf2 DIL-2 DIL2 FLS353 GD:C20orf1 HCA519 HCTP4 REPP86 p100 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000922 | Spindle pole | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | TAS | molecular_function |
| GO:0005525 | GTP binding | TAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005819 | Spindle | ISS | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0032147 | Activation of protein kinase activity | IDA | biological_process |
| GO:0060236 | Regulation of mitotic spindle organization | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6632992136 | 0.0000118688 | 0.9999902473 | 0.0071627451 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7882995439 |
| GSE13712_SHEAR | Down | -0.1871122697 |
| GSE13712_STATIC | Down | -0.8231716744 |
| GSE19018 | Up | 0.3446769311 |
| GSE19899_A1 | Down | -2.3970009170 |
| GSE19899_A2 | Down | -4.5024429916 |
| PubMed_21979375_A1 | Down | -3.9160056073 |
| PubMed_21979375_A2 | Down | -4.5387298395 |
| GSE35957 | Down | -3.7682019943 |
| GSE36640 | Down | -4.1170793798 |
| GSE54402 | Down | -1.3906083215 |
| GSE9593 | Down | -1.7053859193 |
| GSE43922 | Down | -1.5652494988 |
| GSE24585 | Up | 0.1424098568 |
| GSE37065 | Down | -1.1789607382 |
| GSE28863_A1 | Down | -0.4538814588 |
| GSE28863_A2 | Up | 1.2275651146 |
| GSE28863_A3 | Down | -0.3913204779 |
| GSE28863_A4 | Up | 0.5441929014 |
| GSE48662 | Down | -1.9254860123 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041448 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26952515 | The aim of the present study was to investigate Ki-67, TPX2, TOP2A and hTERT mRNA expression levels in specimens from patients with GISTs to define relationships between proliferation activity and biological potential and progression of the disease |
| 26952515 | We measured Ki-67, TPX2, TOP2A and hTERT mRNA levels using quantitative real-time reverse transcription PCR (RQ RT PCR) |
| 26952515 | The highest Ki-67, TPX2, TOP2A and hTERT mRNA expression levels were found in the highly proliferative BLs (18 specimens), in comparison with GISTs (137 specimens) and LMSs (9 specimens) |
| 26952515 | We observed association between higher Ki-67, TPX2 and hTERT mRNA levels and the GISTs with malignant potential |
| 26952515 | Univariate analysis (57 patients with available follow-up information) of survival (Kaplan Meier curves method) revealed a correlation between higher levels of TPX2, Ki-67 and hTERT markers and shorter event-free survival (EFS) or poorer overall survival (OS) |
| 26952515 | Proliferation markers of Ki-67, TPX2, TOP2A and hTERT are suitable markers for detection the proliferation activity and telomerase activity of these tumors |
| 26952515 | Furthermore, the assessment of TPX2, Ki-67 and hTERT expression levels is appropriate for determination of malignant potential of GISTs |
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