HCSGD entry for DKK1

1. General information

Official gene symbolDKK1
Entrez ID22943
Gene full namedickkopf WNT signaling pathway inhibitor 1
Other gene symbolsDKK-1 SK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA ISSbiological_process
GO:0000904Cell morphogenesis involved in differentiationIEAbiological_process
GO:0001706Endoderm formationIEAbiological_process
GO:0001707Mesoderm formationIEAbiological_process
GO:0001942Hair follicle developmentIEAbiological_process
GO:0002090Regulation of receptor internalizationIDAbiological_process
GO:0004871Signal transducer activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0008083Growth factor activityTASmolecular_function
GO:0010469Regulation of receptor activityIDAbiological_process
GO:0030326Embryonic limb morphogenesisIEAbiological_process
GO:0030514Negative regulation of BMP signaling pathwayIEAbiological_process
GO:0030900Forebrain developmentIEAbiological_process
GO:0031333Negative regulation of protein complex assemblyIDAbiological_process
GO:0032526Response to retinoic acidIEAbiological_process
GO:0033137Negative regulation of peptidyl-serine phosphorylationIDAbiological_process
GO:0042662Negative regulation of mesodermal cell fate specificationIDAbiological_process
GO:0042663Regulation of endodermal cell fate specificationIDAbiological_process
GO:0048019Receptor antagonist activityIDAmolecular_function
GO:0048642Negative regulation of skeletal muscle tissue developmentIEAbiological_process
GO:0050750Low-density lipoprotein particle receptor bindingIDAmolecular_function
GO:0060325Face morphogenesisIEAbiological_process
GO:0060394Negative regulation of pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0090082Positive regulation of heart induction by negative regulation of canonical Wnt signaling pathwayISSbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDA IGIbiological_process
GO:0090244Wnt signaling pathway involved in somitogenesisIEAbiological_process
GO:1900116Extracellular negative regulation of signal transductionIDAbiological_process
GO:1901296Negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitmentIDAbiological_process
GO:2000272Negative regulation of receptor activityIDAbiological_process
GO:2000726Negative regulation of cardiac muscle cell differentiationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02604934840.00013542420.37755776430.0203685714

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.2907082150
GSE13712_SHEARUp2.0757051221
GSE13712_STATICUp1.2546738180
GSE19018Down-1.4106803832
GSE19899_A1Down-2.4635525026
GSE19899_A2Down-2.3034440474
PubMed_21979375_A1Down-1.9089309406
PubMed_21979375_A2Down-2.8562488667
GSE35957Up0.1200292261
GSE36640Down-0.4140630177
GSE54402Down-1.7688623433
GSE9593Up2.5817314252
GSE43922Down-2.0609396230
GSE24585Up0.4680083244
GSE37065Up0.0177764323
GSE28863_A1Down-1.5912106889
GSE28863_A2Down-0.5096554605
GSE28863_A3Down-0.4988284024
GSE28863_A4Up0.2865334744
GSE48662Down-1.3171613008

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29a-3pMIMAT0000086MIRT003609Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20551325
hsa-miR-31-5pMIMAT0000089MIRT005874Immunoprecipitaion//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI21048943
hsa-miR-1MIMAT0000416MIRT023613MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24481601Induction of the Wnt antagonist Dickkopf-1 (Dkk1) is involved in tissue repair during inflammation and cellular injury
24481601In this study, we aimed to identify the biological role of Dkk1 in human reflux esophagitis with respect to cell growth and regulation of Wnt signaling
24481601Esophageal biopsies from reflux-esophagitis patients (n = 15) and healthy individuals (n = 10) were characterized in terms of Dkk1 expression
24481601The role of Dkk1 in response to acid-mediated epithelial injury was analyzed by cellular assays in vitro utilizing squamous esophageal epithelial cell lines (EPC1-hTERT, EPC2-hTERT, and HEEC)
24481601Dkk1 was significantly overexpressed in human reflux-esophagitis tissue compared with healthy esophageal mucosa at transcriptional and translational levels
24481601After acute and chronic acid (pH 4) exposure, esophageal squamous epithelial cell lines expressed and secreted high levels of Dkk1 in response to stress-associated DNA injury
24481601High extracellular levels of human recombinant Dkk1 inhibited epithelial cell growth and induced cellular senescence in vitro, as demonstrated by reduced cell proliferation, G0/G1 cell cycle arrest, elevated senescence-associated beta-galactosidase activity, and upregulation of p16
24481601Acid pulsing induced Dkk1-mediated senescence, which was directly linked to the ability of Dkk1 to antagonize the canonical Wnt/beta-catenin signaling
24481601In healthy esophageal mucosa, Dkk1 expression was associated with low expression of transcriptionally active beta-catenin, while in reflux-esophagitis tissue, Dkk1 overexpression correlated with increased senescence-associated beta-galactosidase activity and p16 upregulation
24481601The data indicate that, in human reflux esophagitis, Dkk1 functions as a secreted growth inhibitor by suppressing Wnt/beta-catenin signaling and promoting cellular senescence
24286133Moreover, transfection with DKK-3, DKK-4, or SOST, which are inhibitors of Wnt signaling, blocked Wnt signaling-mediated TNF-alpha activation; these effects were not observed for DKK-1 or DKK-2
24130040Treatment with 100 ng/mL Dickkopf-1 (DKK1), a Wnt/beta-catenin signaling inhibitor or beta-catenin siRNA for 48 h could reverse the senescent features of SLE BM-MSCs
19540374The reduced capacity of NUSC to form osteoblasts was associated with significantly elevated secretion of Dickkopf-1 (Dkk-1) which is an important inhibitor of Wnt signalling during osteogenesis, compared to BMSC
19540374Our results suggest that the development of fracture non union is linked with a localised reduced capacity of cells to undergo osteogenesis, which in turn is associated with increased cell senescence and Dkk-1 secretion
18258400CD9 antigen, MHC class I chain-related sequence A (MICA) and cell division cycle 37 homolog (CDC37) were up-regulated, and bone morphogenetic protein 4 (BMP4), dickkopf-1 (DKK1), and transcription factor 7-like 1 (TCF7L1) were down-regulated in old cells
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