HCSGD entry for FOXF1

1. General information

Official gene symbolFOXF1
Entrez ID2294
Gene full nameforkhead box F1
Other gene symbolsACDMPV FKHL5 FREAC1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIBAbiological_process
GO:0001568Blood vessel developmentIMPbiological_process
GO:0001570VasculogenesisIEAbiological_process
GO:0001701In utero embryonic developmentIMPbiological_process
GO:0001756SomitogenesisIEAbiological_process
GO:0001763Morphogenesis of a branching structureIMPbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationIEAbiological_process
GO:0003197Endocardial cushion developmentIMPbiological_process
GO:0003214Cardiac left ventricle morphogenesisIMPbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003690Double-stranded DNA bindingIBAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIBAmolecular_function
GO:0005634NucleusICcellular_component
GO:0005667Transcription factor complexIBAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIBAbiological_process
GO:0007224Smoothened signaling pathwayIEAbiological_process
GO:0007368Determination of left/right symmetryIEAbiological_process
GO:0007389Pattern specification processIBAbiological_process
GO:0007494Midgut developmentIMPbiological_process
GO:0007507Heart developmentIMPbiological_process
GO:0008134Transcription factor bindingIBAmolecular_function
GO:0008301DNA binding, bendingIBAmolecular_function
GO:0010811Positive regulation of cell-substrate adhesionIEAbiological_process
GO:0014822Detection of woundingIEAbiological_process
GO:0016337Cell-cell adhesionIEAbiological_process
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0030323Respiratory tube developmentIMPbiological_process
GO:0030324Lung developmentIMPbiological_process
GO:0030335Positive regulation of cell migrationIEAbiological_process
GO:0031016Pancreas developmentIMPbiological_process
GO:0043305Negative regulation of mast cell degranulationIEAbiological_process
GO:0043565Sequence-specific DNA bindingISSmolecular_function
GO:0044212Transcription regulatory region DNA bindingIEAmolecular_function
GO:0045198Establishment of epithelial cell apical/basal polarityIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIBAbiological_process
GO:0048286Lung alveolus developmentIEAbiological_process
GO:0048371Lateral mesodermal cell differentiationIEAbiological_process
GO:0048557Embryonic digestive tract morphogenesisIMPbiological_process
GO:0048565Digestive tract developmentIMPbiological_process
GO:0048613Embryonic ectodermal digestive tract morphogenesisIMPbiological_process
GO:0048617Embryonic foregut morphogenesisIEAbiological_process
GO:0050728Negative regulation of inflammatory responseIEAbiological_process
GO:0051090Regulation of sequence-specific DNA binding transcription factor activityIBAbiological_process
GO:0051145Smooth muscle cell differentiationIEAbiological_process
GO:0051150Regulation of smooth muscle cell differentiationIEAbiological_process
GO:0060426Lung vasculature developmentIMPbiological_process
GO:0060438Trachea developmentIEAbiological_process
GO:0060441Epithelial tube branching involved in lung morphogenesisIEAbiological_process
GO:0060446Branching involved in open tracheal system developmentIMPbiological_process
GO:0060461Right lung morphogenesisIEAbiological_process
GO:0060463Lung lobe morphogenesisIEAbiological_process
GO:0060841Venous blood vessel developmentIMPbiological_process
GO:0061030Epithelial cell differentiation involved in mammary gland alveolus developmentIEAbiological_process
GO:0071345Cellular response to cytokine stimulusIEAbiological_process
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
GO:0072001Renal system developmentIMPbiological_process
GO:0072189Ureter developmentIMPbiological_process
GO:0090131Mesenchyme migrationIEAbiological_process
GO:0097070Ductus arteriosus closureIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01567994760.94586997830.31021299771.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.7741016734
GSE13712_SHEARUp1.8034794775
GSE13712_STATICUp2.6349713717
GSE19018Down-0.1856614523
GSE19899_A1Up0.0914448559
GSE19899_A2Up0.0533330359
PubMed_21979375_A1Down-0.4095784337
PubMed_21979375_A2Up0.3431275965
GSE35957Up0.2751068997
GSE36640Up0.2909927586
GSE54402Down-0.3259158386
GSE9593Down-0.0336729194
GSE43922Up0.2304334457
GSE24585Up0.2155425623
GSE37065Down-0.0123971748
GSE28863_A1Down-0.1132979417
GSE28863_A2Up0.0905999263
GSE28863_A3Up0.2329528112
GSE28863_A4Up0.0630252640
GSE48662Down-0.0120323981

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

15136151Genes upregulated in Shh(-/-);Gli3(-/-) relative to Shh(-/-) lung include Wnt2 and, surprisingly, Foxf1 whose expression has been reported to be Shh-dependent
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