HCSGD entry for ATF6
1. General information
| Official gene symbol | ATF6 |
|---|---|
| Entrez ID | 22926 |
| Gene full name | activating transcription factor 6 |
| Other gene symbols | ATF6A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005635 | Nuclear envelope | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006457 | Protein folding | TAS | biological_process |
| GO:0006950 | Response to stress | TAS | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0006990 | Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2040564188 | 0.2206661031 | 0.8714861269 | 0.9044023198 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2141863765 |
| GSE13712_SHEAR | Down | -0.7973316947 |
| GSE13712_STATIC | Down | -0.7560852395 |
| GSE19018 | Up | 0.6176839820 |
| GSE19899_A1 | Down | -0.6121816114 |
| GSE19899_A2 | Down | -0.0162546885 |
| PubMed_21979375_A1 | Down | -0.2478144031 |
| PubMed_21979375_A2 | Up | 0.1274432184 |
| GSE35957 | Up | 0.2193893733 |
| GSE36640 | Up | 0.9734907077 |
| GSE54402 | Down | -0.2704387619 |
| GSE9593 | Up | 0.7307216205 |
| GSE43922 | Up | 0.0978407678 |
| GSE24585 | Up | 0.2189263612 |
| GSE37065 | Up | 0.0761199799 |
| GSE28863_A1 | Down | -0.2369056205 |
| GSE28863_A2 | Up | 0.2845611981 |
| GSE28863_A3 | Down | -0.4982121426 |
| GSE28863_A4 | Down | -0.1954485600 |
| GSE48662 | Up | 0.1772473521 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-503-5p | MIMAT0002874 | MIRT000650 | Luciferase reporter assay | Functional MTI | 19956200 |
| hsa-miR-424-5p | MIMAT0001341 | MIRT000658 | Luciferase reporter assay | Functional MTI | 19956200 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT019158 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-191-5p | MIMAT0000440 | MIRT045796 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25149687 | Results show that in replicative senescence and CuSO4-SIPS, immunoglobulin binding protein, calnexin, protein disulfide isomerase, and ER oxireductin-1 levels adjust to restore proteostasis and inositol-requiring enzyme-1 (IRE1)-, activating transcription factor 6 (ATF6)-, and pancreatic ER kinase (PERK)-mediated unfolded protein response are activated |
| 25149687 | However, H2O2-SIPS does not exhibit IRE1 and ATF6 pathways activation but a PERK-mediated upregulation of CCAAT/enhancer-binding protein homologous protein, showing that CuSO4-SIPS mimics better the endoplasmic reticulum molecular events of replicative senescence than H2O2-SIPS |
| 22548801 | Interestingly, the depletion of PERK but not ATF6 and IRE1 also induces cellular senescence, which was rescued by additional depletion of Akt |
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