HCSGD entry for PLA2R1

1. General information

Official gene symbolPLA2R1
Entrez ID22925
Gene full namephospholipase A2 receptor 1, 180kDa
Other gene symbolsCLEC13C PLA2-R PLA2G1R PLA2IR PLA2R
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001816Cytokine productionIMPbiological_process
GO:0004872Receptor activityIDAmolecular_function
GO:0005576Extracellular regionISS NAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0006898Receptor-mediated endocytosisIDA IEAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0030246Carbohydrate bindingIEAmolecular_function
GO:0043235Receptor complexIDAcellular_component
GO:0043274Phospholipase bindingIEA IPImolecular_function
GO:0043517Positive regulation of DNA damage response, signal transduction by p53 class mediatorIMPbiological_process
GO:0072593Reactive oxygen species metabolic processIDAbiological_process
GO:0090238Positive regulation of arachidonic acid secretionISSbiological_process
GO:0090399Replicative senescenceIMPbiological_process
GO:0090403Oxidative stress-induced premature senescenceIMPbiological_process
GO:1900138Negative regulation of phospholipase A2 activityISSbiological_process
GO:1900139Negative regulation of arachidonic acid secretionISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05337453740.35523486950.50530895361.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0292507322
GSE13712_SHEARDown-0.4304680862
GSE13712_STATICDown-0.1246804488
GSE19018Up0.0899843411
GSE19899_A1Up0.0954894168
GSE19899_A2Up0.0355395099
PubMed_21979375_A1Down-0.3138103098
PubMed_21979375_A2Up0.0133634643
GSE35957Up0.1952917967
GSE36640Up1.6252352883
GSE54402Down-0.4464853986
GSE9593Up0.2877268608
GSE43922Up0.0036820154
GSE24585Up0.2664457160
GSE37065Up0.5571008643
GSE28863_A1Up0.9041842163
GSE28863_A2Up0.8896741867
GSE28863_A3Down-0.6056928664
GSE28863_A4Down-0.5071067197
GSE48662Up0.3800797775

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19197340The M-type receptor PLA2R regulates senescence through the p53 pathway
19197340We report that knockdown of the M-type receptor PLA2R (phospholipase A2 receptor) prevents the onset of replicative senescence and diminishes stress-induced senescence
19197340Interestingly, expression of PLA2R increases during replicative senescence, and its ectopic expression results in premature senescence
19197340We show that PLA2R regulates senescence in a reactive oxygen species-DNA damage-p53-dependent manner
19197340Taken together, our study identifies PLA2R as a potential new tumour suppressor gene crucial in the induction of cellular senescence through the activation of the p53 pathway
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