HCSGD entry for MSRB2
1. General information
| Official gene symbol | MSRB2 |
|---|---|
| Entrez ID | 22921 |
| Gene full name | methionine sulfoxide reductase B2 |
| Other gene symbols | CBS-1 CBS1 MSRB PILB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0003779 | Actin binding | ISS | molecular_function |
| GO:0005739 | Mitochondrion | ISS | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0008270 | Zinc ion binding | ISS | molecular_function |
| GO:0030041 | Actin filament polymerization | ISS | biological_process |
| GO:0030091 | Protein repair | IEA ISS | biological_process |
| GO:0033743 | Peptide-methionine (R)-S-oxide reductase activity | IEA ISS | molecular_function |
| GO:2001141 | Regulation of RNA biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9750385586 | 0.0326901523 | 0.9999902473 | 0.3411726804 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1142284811 |
| GSE13712_SHEAR | Down | -0.2724657429 |
| GSE13712_STATIC | Down | -0.1016686394 |
| GSE19018 | Up | 0.1014874472 |
| GSE19899_A1 | Down | -0.9352175837 |
| GSE19899_A2 | Down | -0.1449231861 |
| PubMed_21979375_A1 | Down | -0.4367207316 |
| PubMed_21979375_A2 | Down | -1.0210156211 |
| GSE35957 | Down | -0.0397187272 |
| GSE36640 | Down | -0.5912429323 |
| GSE54402 | Down | -0.3235973034 |
| GSE9593 | Down | -0.1929700971 |
| GSE43922 | Down | -0.3463576550 |
| GSE24585 | Up | 0.5358800408 |
| GSE37065 | Down | -0.0035922587 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0935545097 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23206970 | Both msrB genes are constitutively expressed, suggesting that the MsrB enzyme plays an essential role in repairing oxidative damages that appear to be primarily caused by physiological cell aging in E |
| 15680234 | Protein-bound methionine sulfoxide diastereoisomers S and R are repaired by the combined action of the enzymes MsrA and MsrB that are subsequently regenerated by thioredoxin/thioredoxin reductase |
| 15680234 | More recently, we have shown that gene expression of both MsrA and MsrB2 (Cbs-1) is decreased during replicative senescence of WI-38 fibroblasts, and this decline is associated with an alteration in catalytic activity and the accumulation of oxidized protein |
| 14759519 | The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts |
| 14759519 | In contrast to other oxidative modifications of amino acids, methionine sulfoxide can be enzymatically reduced back to methionine in proteins by the peptide methionine sulfoxide reductase system, composed of MsrA and MsrB |
| 14759519 | The expression of MsrA and one member of the MsrB family, hCBS-1, was analyzed during replicative senescence of WI-38 human fibroblasts |
| 14759519 | These results suggest that downregulation of MsrA and hCBS-1 can alter the ability of senescent cells to cope with oxidative stress, hence contributing to the age-related accumulation of oxidative damage |
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