HCSGD entry for FAN1

1. General information

Official gene symbolFAN1
Entrez ID22909
Gene full nameFANCD2/FANCI-associated nuclease 1
Other gene symbolsKIAA1018 KMIN MTMR15
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingTASmolecular_function
GO:0000724Double-strand break repair via homologous recombinationIMPbiological_process
GO:0000737DNA catabolic process, endonucleolyticIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0004528Phosphodiesterase I activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0006281DNA repairIEA IMPbiological_process
GO:0006289Nucleotide-excision repairIMPbiological_process
GO:0006308DNA catabolic processIDAbiological_process
GO:00084095'-3' exonuclease activityIDAmolecular_function
GO:00171085'-flap endonuclease activityIDAmolecular_function
GO:0033683Nucleotide-excision repair, DNA incisionIDA IMPbiological_process
GO:0043130Ubiquitin bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95457821890.12575445840.99999024730.6821894270

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1187192701
GSE13712_SHEARUp0.1817615778
GSE13712_STATICDown-0.1914149105
GSE19018Down-0.2057102816
GSE19899_A1Down-0.1566526529
GSE19899_A2Up0.2197634930
PubMed_21979375_A1Down-0.1468021477
PubMed_21979375_A2Up0.0184498017
GSE35957Down-0.0632326526
GSE36640Down-0.1236503792
GSE54402Up0.0127280902
GSE9593Down-0.0898082218
GSE43922Up0.0375455862
GSE24585Down-0.1952995091
GSE37065Down-0.1012173099
GSE28863_A1Up0.0123030378
GSE28863_A2Down-0.0261481065
GSE28863_A3Down-0.7460833159
GSE28863_A4Up0.0742026789
GSE48662Down-0.3772207554

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-940MIMAT0004983MIRT036619CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.