HCSGD entry for ZNF365
1. General information
| Official gene symbol | ZNF365 |
|---|---|
| Entrez ID | 22891 |
| Gene full name | zinc finger protein 365 |
| Other gene symbols | Su48 UAN ZNF365D |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0442857452 | 0.9314520003 | 0.4692613124 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4528916489 |
| GSE13712_SHEAR | Down | -0.4097311737 |
| GSE13712_STATIC | Down | -0.2655623113 |
| GSE19018 | Down | -0.3854591357 |
| GSE19899_A1 | Up | 0.2832994019 |
| GSE19899_A2 | Down | -0.0020545944 |
| PubMed_21979375_A1 | Up | 0.1907438775 |
| PubMed_21979375_A2 | Up | 0.4434666241 |
| GSE35957 | Up | 0.6317118281 |
| GSE36640 | Up | 0.3377920561 |
| GSE54402 | Up | 0.5266655526 |
| GSE9593 | Up | 0.2932308204 |
| GSE43922 | Up | 0.3932828143 |
| GSE24585 | Up | 0.0157497843 |
| GSE37065 | Up | 0.0917031281 |
| GSE28863_A1 | Up | 0.0211179490 |
| GSE28863_A2 | Up | 0.1216796152 |
| GSE28863_A3 | Up | 0.1133987224 |
| GSE28863_A4 | Up | 0.1709554199 |
| GSE48662 | Up | 0.0912597841 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016433 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025758 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23776040 | ZNF365 promotes stability of fragile sites and telomeres |
| 23776040 | Here, analysis of p53-regulated genes activated in the setting of telomere dysfunction identified Zfp365 (ZNF365 in humans) as a direct p53 target that promotes genome stability |
| 23776040 | Germline polymorphisms in the ZNF365 locus are associated with increased cancer risk, including those associated with telomere dysfunction |
| 23776040 | On the mechanistic level, ZNF365 suppresses expression of a subset of common fragile sites, including telomeres |
| 23776040 | In the absence of ZNF365, defective telomeres engage in aberrant recombination of telomere ends, leading to increased telomere sister chromatid exchange and formation of anaphase DNA bridges, including ultra-fine DNA bridges, and ultimately increased cytokinesis failure and aneuploidy |
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