HCSGD entry for FKBP5
1. General information
| Official gene symbol | FKBP5 |
|---|---|
| Entrez ID | 2289 |
| Gene full name | FK506 binding protein 5 |
| Other gene symbols | AIG6 FKBP51 FKBP54 P54 PPIase Ptg-10 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000413 | Protein peptidyl-prolyl isomerization | IBA IDA | biological_process |
| GO:0003755 | Peptidyl-prolyl cis-trans isomerase activity | IBA IDA | molecular_function |
| GO:0005528 | FK506 binding | IBA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006457 | Protein folding | IEA TAS | biological_process |
| GO:0016020 | Membrane | IBA | cellular_component |
| GO:0018208 | Peptidyl-proline modification | IBA | biological_process |
| GO:0031072 | Heat shock protein binding | IPI | molecular_function |
| GO:0061077 | Chaperone-mediated protein folding | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9943260210 | 0.0004356483 | 0.9999902473 | 0.0387127517 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5465167921 |
| GSE13712_SHEAR | Down | -0.1048328412 |
| GSE13712_STATIC | Down | -0.2018299067 |
| GSE19018 | Down | -1.2304984262 |
| GSE19899_A1 | Down | -0.2950260967 |
| GSE19899_A2 | Down | -2.3460837508 |
| PubMed_21979375_A1 | Down | -1.4374902628 |
| PubMed_21979375_A2 | Down | -2.2245090439 |
| GSE35957 | Down | -1.3460115185 |
| GSE36640 | Down | -3.7608588239 |
| GSE54402 | Down | -0.0198318983 |
| GSE9593 | Up | 0.0612302273 |
| GSE43922 | Down | -0.8240371052 |
| GSE24585 | Up | 0.0002487702 |
| GSE37065 | Down | -0.6061721666 |
| GSE28863_A1 | Down | -0.3547288884 |
| GSE28863_A2 | Down | -0.3235137666 |
| GSE28863_A3 | Up | 0.2484237253 |
| GSE28863_A4 | Up | 0.0939543515 |
| GSE48662 | Down | -0.5467070928 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT030843 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038745 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-328-3p | MIMAT0000752 | MIRT043776 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT050456 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26371764 | In the HIPP of MDD subjects, several genes involved in neuroprotection and in stress response (FKBP5, CRH) showed altered levels of mRNA |
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