HCSGD entry for FKBP4
1. General information
| Official gene symbol | FKBP4 |
|---|---|
| Entrez ID | 2288 |
| Gene full name | FK506 binding protein 4, 59kDa |
| Other gene symbols | FKBP51 FKBP52 FKBP59 HBI Hsp56 PPIase p52 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000413 | Protein peptidyl-prolyl isomerization | IBA IDA | biological_process |
| GO:0003755 | Peptidyl-prolyl cis-trans isomerase activity | IBA IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005528 | FK506 binding | IBA TAS | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA ISS | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0006457 | Protein folding | IEA TAS | biological_process |
| GO:0006463 | Steroid hormone receptor complex assembly | IEA | biological_process |
| GO:0006825 | Copper ion transport | IEA | biological_process |
| GO:0007566 | Embryo implantation | IEA | biological_process |
| GO:0010977 | Negative regulation of neuron projection development | ISS | biological_process |
| GO:0016020 | Membrane | IBA | cellular_component |
| GO:0018208 | Peptidyl-proline modification | IBA | biological_process |
| GO:0030521 | Androgen receptor signaling pathway | IEA | biological_process |
| GO:0030674 | Protein binding, bridging | TAS | molecular_function |
| GO:0030850 | Prostate gland development | IEA | biological_process |
| GO:0031072 | Heat shock protein binding | IEA IPI | molecular_function |
| GO:0031111 | Negative regulation of microtubule polymerization or depolymerization | ISS | biological_process |
| GO:0031115 | Negative regulation of microtubule polymerization | IEA | biological_process |
| GO:0031503 | Protein complex localization | IEA | biological_process |
| GO:0032767 | Copper-dependent protein binding | IEA | molecular_function |
| GO:0035259 | Glucocorticoid receptor binding | IEA | molecular_function |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0044295 | Axonal growth cone | IEA ISS | cellular_component |
| GO:0046661 | Male sex differentiation | IEA | biological_process |
| GO:0048156 | Tau protein binding | IEA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0051219 | Phosphoprotein binding | IEA | molecular_function |
| GO:0061077 | Chaperone-mediated protein folding | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1543070818 | 0.5923962159 | 0.7816621824 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1241433019 |
| GSE13712_SHEAR | Up | 0.0446331528 |
| GSE13712_STATIC | Up | 0.1676131807 |
| GSE19018 | Down | -0.1702252784 |
| GSE19899_A1 | Up | 0.2304241058 |
| GSE19899_A2 | Up | 0.6923081247 |
| PubMed_21979375_A1 | Up | 0.4238704769 |
| PubMed_21979375_A2 | Up | 0.2614661493 |
| GSE35957 | Down | -0.3790149036 |
| GSE36640 | Down | -0.3987627869 |
| GSE54402 | Up | 0.5535158564 |
| GSE9593 | Down | -0.2194476492 |
| GSE43922 | Up | 0.5584439809 |
| GSE24585 | Down | -0.4094103825 |
| GSE37065 | Down | -0.0864412630 |
| GSE28863_A1 | Down | -0.1911791112 |
| GSE28863_A2 | Up | 0.0263838981 |
| GSE28863_A3 | Down | -0.1213356382 |
| GSE28863_A4 | Up | 0.0443567083 |
| GSE48662 | Up | 0.1418358520 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-760 | MIMAT0004957 | MIRT036772 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037008 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037530 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038093 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99b-3p | MIMAT0004678 | MIRT038526 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039622 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040589 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040812 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041945 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-328-3p | MIMAT0000752 | MIRT043773 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045461 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048140 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049584 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050423 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
