HCSGD entry for LPHN1
1. General information
| Official gene symbol | LPHN1 |
|---|---|
| Entrez ID | 22859 |
| Gene full name | latrophilin 1 |
| Other gene symbols | CIRL1 CL1 LEC2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | ISS | cellular_component |
| GO:0007157 | Heterophilic cell-cell adhesion | ISS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007218 | Neuropeptide signaling pathway | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016524 | Latrotoxin receptor activity | ISS | molecular_function |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0030246 | Carbohydrate binding | IEA | molecular_function |
| GO:0030424 | Axon | ISS | cellular_component |
| GO:0030426 | Growth cone | ISS | cellular_component |
| GO:0035584 | Calcium-mediated signaling using intracellular calcium source | ISS | biological_process |
| GO:0042734 | Presynaptic membrane | ISS | cellular_component |
| GO:0043005 | Neuron projection | ISS | cellular_component |
| GO:0045202 | Synapse | ISS | cellular_component |
| GO:0050839 | Cell adhesion molecule binding | ISS | molecular_function |
| GO:0090129 | Positive regulation of synapse maturation | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7129964097 | 0.1655968390 | 0.9999902473 | 0.7876173473 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0737230509 |
| GSE13712_SHEAR | Down | -0.5713543697 |
| GSE13712_STATIC | Down | -0.1676679091 |
| GSE19018 | Down | -0.3005179630 |
| GSE19899_A1 | Down | -0.0538243630 |
| GSE19899_A2 | Down | -0.1442121742 |
| PubMed_21979375_A1 | Down | -0.0536729085 |
| PubMed_21979375_A2 | Down | -0.1007863395 |
| GSE35957 | Down | -0.2650792225 |
| GSE36640 | Up | 0.2765516612 |
| GSE54402 | Down | -0.3000274536 |
| GSE9593 | Up | 0.0323702050 |
| GSE43922 | Up | 0.0545096506 |
| GSE24585 | Down | -0.4548772461 |
| GSE37065 | Down | -0.0353100713 |
| GSE28863_A1 | Up | 0.4883704909 |
| GSE28863_A2 | Down | -0.1229235081 |
| GSE28863_A3 | Up | 0.4625832637 |
| GSE28863_A4 | Down | -0.0026750210 |
| GSE48662 | Up | 0.2584460042 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT026993 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031502 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-328-3p | MIMAT0000752 | MIRT043821 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 9434634 | Two different fibroblast lines (CL1; CL2) at the fourth subculture were passaged up to replicative senescence to model aging processes in vitro |
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