HCSGD entry for ICK
1. General information
| Official gene symbol | ICK |
|---|---|
| Entrez ID | 22858 |
| Gene full name | intestinal cell (MAK-like) kinase |
| Other gene symbols | ECO LCK2 MRK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004693 | Cyclin-dependent protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9535569507 | 0.0178386004 | 0.9999902473 | 0.2614308463 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6664340192 |
| GSE13712_SHEAR | Down | -0.0606457837 |
| GSE13712_STATIC | Down | -0.1950996521 |
| GSE19018 | Up | 0.6000551481 |
| GSE19899_A1 | Down | -0.5405650860 |
| GSE19899_A2 | Down | -0.5161953931 |
| PubMed_21979375_A1 | Down | -1.2121503111 |
| PubMed_21979375_A2 | Down | -0.4547768029 |
| GSE35957 | Up | 0.5540992515 |
| GSE36640 | Down | -0.1203205860 |
| GSE54402 | Down | -0.6427526196 |
| GSE9593 | Down | -0.2710444508 |
| GSE43922 | Down | -0.8201598607 |
| GSE24585 | Up | 0.1058173111 |
| GSE37065 | Down | -0.2179420121 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.1288009030 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024721 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026365 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027299 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
