HCSGD entry for CPEB3

1. General information

Official gene symbolCPEB3
Entrez ID22849
Gene full namecytoplasmic polyadenylation element binding protein 3
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000166Nucleotide bindingIEAmolecular_function
GO:0000900Translation repressor activity, nucleic acid bindingISSmolecular_function
GO:0003723RNA bindingIDAmolecular_function
GO:0003730MRNA 3'-UTR bindingIDA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDA ISScellular_component
GO:0006412TranslationIDA ISSbiological_process
GO:0007616Long-term memoryISSbiological_process
GO:0008135Translation factor activity, nucleic acid bindingIDA ISSmolecular_function
GO:0017148Negative regulation of translationIDAbiological_process
GO:0030014CCR4-NOT complexIDAcellular_component
GO:0030425DendriteISScellular_component
GO:0035613RNA stem-loop bindingISSmolecular_function
GO:0035925MRNA 3'-UTR AU-rich region bindingISSmolecular_function
GO:0043005Neuron projectionIDA ISScellular_component
GO:0045202SynapseISScellular_component
GO:0045727Positive regulation of translationISSbiological_process
GO:0048167Regulation of synaptic plasticityISSbiological_process
GO:0060213Positive regulation of nuclear-transcribed mRNA poly(A) tail shorteningIDAbiological_process
GO:0060998Regulation of dendritic spine developmentISSbiological_process
GO:0060999Positive regulation of dendritic spine developmentISSbiological_process
GO:00611583'-UTR-mediated mRNA destabilizationIDAbiological_process
GO:0071230Cellular response to amino acid stimulusIDA ISSbiological_process
GO:0097440Apical dendriteISScellular_component
GO:1900153Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayIDAbiological_process
GO:1900248Negative regulation of cytoplasmic translational elongationISSbiological_process
GO:1900365Positive regulation of mRNA polyadenylationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.46761984730.71638475360.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1506634069
GSE13712_SHEARUp0.0671540353
GSE13712_STATICUp0.2378373759
GSE19018Down-0.2684959950
GSE19899_A1Up0.0852724097
GSE19899_A2Up0.0703862120
PubMed_21979375_A1Up0.1312315890
PubMed_21979375_A2Down-0.2439539161
GSE35957Down-0.0565579804
GSE36640Up0.1633903637
GSE54402Up0.0113338156
GSE9593Down-0.1958651079
GSE43922Up0.0732949609
GSE24585Up0.4609863037
GSE37065Up0.2002876987
GSE28863_A1Up0.0342671871
GSE28863_A2Up0.0342457190
GSE28863_A3Up0.1469062469
GSE28863_A4Up0.0527925298
GSE48662Down-0.1688407140

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26a-5pMIMAT0000082MIRT005588Luciferase reporter assay//Northern blot//qRT-PCRFunctional MTI20660482
hsa-miR-26a-5pMIMAT0000082MIRT005588CLASHFunctional MTI (Weak)23622248
hsa-miR-29a-3pMIMAT0000086MIRT005591Luciferase reporter assay//Northern blot//qRT-PCRFunctional MTI20660482
hsa-miR-23b-3pMIMAT0000418MIRT023472SequencingFunctional MTI (Weak)20371350
hsa-miR-196a-5pMIMAT0000226MIRT026085SequencingFunctional MTI (Weak)20371350
hsa-miR-21-5pMIMAT0000076MIRT030711MicroarrayFunctional MTI (Weak)18591254
hsa-miR-320aMIMAT0000510MIRT044792CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26915047New Phosphospecific Antibody Reveals Isoform-Specific Phosphorylation of CPEB3 Protein
26915047This region is highly conserved between CPEBs-2-4 and contains a putative phosphorylation consensus, overlapping with the exon seven of CPEB3
26915047Here, focusing on the alternatively spliced region of CPEB3, we determined that putative neuronal isoforms of CPEB3 are phosphorylated
26915047Using a new phosphospecific antibody directed to the phosphorylation consensus we found Protein Kinase A and Calcium/Calmodulin-dependent Protein Kinase II to robustly phosphorylate CPEB3 in vitro and in primary hippocampal neurons
26915047Interestingly, status epilepticus induced by systemic kainate injection in mice led to specific upregulation of the CPEB3 isoforms containing exon seven
26915047Extensive analysis of CPEB3 phosphorylation in vitro revealed two other phosphorylation sites
26915047In addition, we found plethora of potential kinases that might be targeting the alternatively spliced kinase consensus site of CPEB3
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