HCSGD entry for PHLDA1
1. General information
| Official gene symbol | PHLDA1 |
|---|---|
| Entrez ID | 22822 |
| Gene full name | pleckstrin homology-like domain, family A, member 1 |
| Other gene symbols | DT1P1B11 PHRIP TDAG51 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0021879 | Forebrain neuron differentiation | IEA | biological_process |
| GO:0030659 | Cytoplasmic vesicle membrane | IEA | cellular_component |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0045210 | FasL biosynthetic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0023479807 | 0.6828086433 | 0.1292912134 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 2.1867388536 |
| GSE13712_SHEAR | Up | 0.5939109724 |
| GSE13712_STATIC | Down | -0.2966520637 |
| GSE19018 | Down | -1.1121560218 |
| GSE19899_A1 | Up | 1.1960783261 |
| GSE19899_A2 | Up | 0.2747806413 |
| PubMed_21979375_A1 | Up | 1.7451160522 |
| PubMed_21979375_A2 | Up | 0.9807664309 |
| GSE35957 | Down | -1.2685460909 |
| GSE36640 | Down | -0.1515319350 |
| GSE54402 | Up | 0.5019664883 |
| GSE9593 | Up | 1.2394870007 |
| GSE43922 | Up | 0.4494866132 |
| GSE24585 | Up | 0.1100992399 |
| GSE37065 | Up | 0.5715439854 |
| GSE28863_A1 | Down | -0.1744538276 |
| GSE28863_A2 | Up | 1.0328999436 |
| GSE28863_A3 | Down | -0.0544458015 |
| GSE28863_A4 | Up | 0.1200989795 |
| GSE48662 | Down | -0.5588372184 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019686 | Microarray | Functional MTI (Weak) | 20215506 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15574883 | In addition to DUSP1 and known p53 and E2F targets, a number of genes such as PHLDA1, NR4A3, and a novel splice variant of STAC were implicated in senescence |
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