HCSGD entry for RASA3
1. General information
| Official gene symbol | RASA3 |
|---|---|
| Entrez ID | 22821 |
| Gene full name | RAS p21 protein activator 3 |
| Other gene symbols | GAP1IP4BP GAPIII |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IEA TAS | molecular_function |
| GO:0005099 | Ras GTPase activator activity | IBA | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0006810 | Transport | IDA | biological_process |
| GO:0006812 | Cation transport | IDA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0015278 | Calcium-release channel activity | IDA | molecular_function |
| GO:0030001 | Metal ion transport | IDA | biological_process |
| GO:0031235 | Intrinsic component of the cytoplasmic side of the plasma membrane | IDA | cellular_component |
| GO:0032320 | Positive regulation of Ras GTPase activity | IBA | biological_process |
| GO:0034220 | Ion transmembrane transport | IDA | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0046580 | Negative regulation of Ras protein signal transduction | IBA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | IEA | biological_process |
| GO:0055085 | Transmembrane transport | IDA | biological_process |
| GO:0070588 | Calcium ion transmembrane transport | IDA | biological_process |
| GO:0072511 | Divalent inorganic cation transport | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4601044603 | 0.2611378481 | 0.9999902473 | 0.9806982879 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0669136862 |
| GSE13712_SHEAR | Up | 0.0824782476 |
| GSE13712_STATIC | Down | -0.1333782444 |
| GSE19018 | Down | -0.1555216465 |
| GSE19899_A1 | Up | 0.0292839437 |
| GSE19899_A2 | Down | -0.0681419134 |
| PubMed_21979375_A1 | Down | -0.7996758151 |
| PubMed_21979375_A2 | Down | -0.2931396490 |
| GSE35957 | Down | -0.3099827543 |
| GSE36640 | Down | -0.3643268592 |
| GSE54402 | Up | 0.6431506646 |
| GSE9593 | Down | -0.0215578591 |
| GSE43922 | Down | -0.0138532172 |
| GSE24585 | Up | 0.0160505738 |
| GSE37065 | Up | 0.1814603373 |
| GSE28863_A1 | Up | 0.4382959138 |
| GSE28863_A2 | Up | 0.1135047667 |
| GSE28863_A3 | Up | 0.2812644326 |
| GSE28863_A4 | Down | -0.0121733723 |
| GSE48662 | Down | -0.2117224032 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017554 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049026 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19944017 | We found that the chromatin modifier-encoding genes Eu-HMTase1, ZMYND11, and RASA3 were overexpressed in adults |
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