HCSGD entry for FKBP1B

1. General information

Official gene symbolFKBP1B
Entrez ID2281
Gene full nameFK506 binding protein 1B, 12.6 kDa
Other gene symbolsFKBP12.6 FKBP1L OTK4 PKBP1L PPIase
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000413Protein peptidyl-prolyl isomerizationIDAbiological_process
GO:0003755Peptidyl-prolyl cis-trans isomerase activityIDA IEAmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005219Ryanodine-sensitive calcium-release channel activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005528FK506 bindingIDA IEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolICcellular_component
GO:0006457Protein foldingIEAbiological_process
GO:0006458'de novo' protein foldingTASbiological_process
GO:0006939Smooth muscle contractionIEAbiological_process
GO:0008152Metabolic processIDAbiological_process
GO:0009749Response to glucoseIEAbiological_process
GO:0010459Negative regulation of heart rateIEA ISSbiological_process
GO:0010880Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumIDAbiological_process
GO:0010881Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionIEA ISSbiological_process
GO:0014808Release of sequestered calcium ion into cytosol by sarcoplasmic reticulumIEAbiological_process
GO:0016020MembraneIDAcellular_component
GO:0018208Peptidyl-proline modificationIBAbiological_process
GO:0019227Neuronal action potential propagationIEAbiological_process
GO:0019855Calcium channel inhibitor activityIDAmolecular_function
GO:0022417Protein maturation by protein foldingTASbiological_process
GO:0030018Z discIDAcellular_component
GO:0030073Insulin secretionIEAbiological_process
GO:0030551Cyclic nucleotide bindingIEAmolecular_function
GO:0032513Negative regulation of protein phosphatase type 2B activityIDAbiological_process
GO:0033017Sarcoplasmic reticulum membraneIBA IEAcellular_component
GO:0033197Response to vitamin EIEAbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0034704Calcium channel complexIDAcellular_component
GO:0035584Calcium-mediated signaling using intracellular calcium sourceTASbiological_process
GO:0042026Protein refoldingTASbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0044325Ion channel bindingIEA ISSmolecular_function
GO:0048680Positive regulation of axon regenerationIEAbiological_process
GO:0051280Negative regulation of release of sequestered calcium ion into cytosolIDAbiological_process
GO:0051284Positive regulation of sequestering of calcium ionIDAbiological_process
GO:0051480Cytosolic calcium ion homeostasisIDA IGIbiological_process
GO:0051775Response to redox stateIDAbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060314Regulation of ryanodine-sensitive calcium-release channel activityIDA IEA IMPbiological_process
GO:0060315Negative regulation of ryanodine-sensitive calcium-release channel activityIDAbiological_process
GO:0061179Negative regulation of insulin secretion involved in cellular response to glucose stimulusIEAbiological_process
GO:0070588Calcium ion transmembrane transportTASbiological_process
GO:0086064Cell communication by electrical coupling involved in cardiac conductionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.10827676760.78876126670.68266914971.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6755837447
GSE13712_SHEARDown-0.1939392763
GSE13712_STATICUp0.1234306427
GSE19018Up0.4946892912
GSE19899_A1Down-0.4982666851
GSE19899_A2Down-0.2079841037
PubMed_21979375_A1Down-0.0287365226
PubMed_21979375_A2Up0.1053061161
GSE35957Up0.3350909857
GSE36640Up0.6880681139
GSE54402Down-0.3734710452
GSE9593Up0.5891233761
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.0629647712

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019735MicroarrayFunctional MTI (Weak)20215506
hsa-miR-26b-5pMIMAT0000083MIRT028949SequencingFunctional MTI (Weak)20371350
hsa-miR-24-3pMIMAT0000080MIRT030378SequencingFunctional MTI (Weak)20371350
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.