HCSGD entry for XRN2
1. General information
| Official gene symbol | XRN2 |
|---|---|
| Entrez ID | 22803 |
| Gene full name | 5'-3' exoribonuclease 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000738 | DNA catabolic process, exonucleolytic | IDA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0004518 | Nuclease activity | TAS | molecular_function |
| GO:0004534 | 5'-3' exoribonuclease activity | IEA TAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006353 | DNA-templated transcription, termination | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006396 | RNA processing | TAS | biological_process |
| GO:0006397 | MRNA processing | IEA | biological_process |
| GO:0006401 | RNA catabolic process | TAS | biological_process |
| GO:0007283 | Spermatogenesis | IEA IEP | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008409 | 5'-3' exonuclease activity | IDA | molecular_function |
| GO:0016049 | Cell growth | IEA ISS | biological_process |
| GO:0016070 | RNA metabolic process | ISS | biological_process |
| GO:0016235 | Aggresome | IDA | cellular_component |
| GO:0090501 | RNA phosphodiester bond hydrolysis | TAS | biological_process |
| GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3705436610 | 0.2040279891 | 0.9999902473 | 0.8749137667 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4898536091 |
| GSE13712_SHEAR | Down | -0.2075254208 |
| GSE13712_STATIC | Down | -0.0194924977 |
| GSE19018 | Down | -0.1817123308 |
| GSE19899_A1 | Down | -0.3616491159 |
| GSE19899_A2 | Up | 0.2411562993 |
| PubMed_21979375_A1 | Down | -0.6169761347 |
| PubMed_21979375_A2 | Down | -0.3032164514 |
| GSE35957 | Down | -0.0813458425 |
| GSE36640 | Down | -0.5757104637 |
| GSE54402 | Up | 0.5519254756 |
| GSE9593 | Up | 0.1101286835 |
| GSE43922 | Up | 0.0050943700 |
| GSE24585 | Up | 0.0297379579 |
| GSE37065 | Up | 0.2248935671 |
| GSE28863_A1 | Up | 0.3478604945 |
| GSE28863_A2 | Up | 0.2375403907 |
| GSE28863_A3 | Down | -0.5218108700 |
| GSE28863_A4 | Up | 0.0409471570 |
| GSE48662 | Down | -0.4709385722 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-9-5p | MIMAT0000441 | MIRT021397 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-760 | MIMAT0004957 | MIRT036710 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045038 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
