HCSGD entry for CASC3
1. General information
| Official gene symbol | CASC3 |
|---|---|
| Entrez ID | 22794 |
| Gene full name | cancer susceptibility candidate 3 |
| Other gene symbols | BTZ MLN51 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006397 | MRNA processing | IEA | biological_process |
| GO:0006417 | Regulation of translation | IEA | biological_process |
| GO:0006950 | Response to stress | IEA | biological_process |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0008298 | Intracellular mRNA localization | IEA | biological_process |
| GO:0008380 | RNA splicing | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030529 | Ribonucleoprotein complex | IEA | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0035145 | Exon-exon junction complex | IDA IEA | cellular_component |
| GO:0042802 | Identical protein binding | IDA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0051028 | MRNA transport | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9964000418 | 0.1378122526 | 0.9999902473 | 0.7152485804 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.1653352003 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | MIRT004991 | Microarray | Functional MTI (Weak) | 17891175 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT004991 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT021901 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037301 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041327 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041656 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043879 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046633 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-182-5p | MIMAT0000259 | MIRT047186 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
