HCSGD entry for FHL2

1. General information

Official gene symbolFHL2
Entrez ID2274
Gene full namefour and a half LIM domains 2
Other gene symbolsAAG11 DRAL FHL-2 SLIM-3 SLIM3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001649Osteoblast differentiationIEAbiological_process
GO:0003713Transcription coactivator activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005925Focal adhesionIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0009725Response to hormoneIMPbiological_process
GO:0015629Actin cytoskeletonIDAcellular_component
GO:0030018Z discIEAcellular_component
GO:0030521Androgen receptor signaling pathwayNASbiological_process
GO:0031430M bandIEAcellular_component
GO:0042802Identical protein bindingIPImolecular_function
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedNASbiological_process
GO:0050681Androgen receptor bindingNASmolecular_function
GO:0055014Atrial cardiac muscle cell developmentIEAbiological_process
GO:0055015Ventricular cardiac muscle cell developmentIEAbiological_process
GO:0060347Heart trabecula formationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.55372126060.15328362520.99999024730.7556805207

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2366623884
GSE13712_SHEARUp0.1223463541
GSE13712_STATICUp0.1534115516
GSE19018Down-0.1911408361
GSE19899_A1Down-0.7035730336
GSE19899_A2Down-0.1009338558
PubMed_21979375_A1Up0.4174784443
PubMed_21979375_A2Up0.2731488242
GSE35957Up0.0168487544
GSE36640Up0.4356883597
GSE54402Down-0.9749987107
GSE9593Up0.5185579758
GSE43922Down-0.0919203627
GSE24585Down-0.2941626904
GSE37065Down-0.3125625068
GSE28863_A1Up0.1162406206
GSE28863_A2Up0.2708240430
GSE28863_A3Up0.0043751575
GSE28863_A4Down-0.0282479901
GSE48662Down-0.0031090627

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT023214Proteomics;MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

15610763Genes specifically up-regulated by transdifferentiation but not by cellular senescence of PrSCs were metalloproteinase 1 tissue inhibitor (Timp1), transgelin (Tagln), gamma 2 actin (Actg2), plasminogen activator inhibitor 1 (Serpinel), insulin-like growth factor binding protein 3 (Igfbp3), parathyroid hormone-like hormone (Pthlp), Tgfb-1, four and a half LIM domains 2 (Fhl-2), hydrogen peroxide-inducible clone 5 (Hic5) and cartilage oligomeric matrix protein (Comp)
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