HCSGD entry for FHIT
1. General information
| Official gene symbol | FHIT |
|---|---|
| Entrez ID | 2272 |
| Gene full name | fragile histidine triad |
| Other gene symbols | AP3Aase FRA3B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0003824 | Catalytic activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006163 | Purine nucleotide metabolic process | IDA | biological_process |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0009117 | Nucleotide metabolic process | TAS | biological_process |
| GO:0016787 | Hydrolase activity | IDA IEA | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0032435 | Negative regulation of proteasomal ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0047710 | Bis(5'-adenosyl)-triphosphatase activity | IDA | molecular_function |
| GO:0072332 | Intrinsic apoptotic signaling pathway by p53 class mediator | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7129997796 | 0.4850498613 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2190089253 |
| GSE13712_SHEAR | Down | -0.3623948952 |
| GSE13712_STATIC | Down | -0.3841234887 |
| GSE19018 | Down | -0.0361731696 |
| GSE19899_A1 | Up | 0.1003757879 |
| GSE19899_A2 | Up | 0.1986671368 |
| PubMed_21979375_A1 | Down | -0.1072123031 |
| PubMed_21979375_A2 | Down | -0.1951929005 |
| GSE35957 | Down | -0.3517271933 |
| GSE36640 | Up | 0.1764364523 |
| GSE54402 | Down | -0.1909093915 |
| GSE9593 | Down | -0.0272913986 |
| GSE43922 | Down | -0.0918633711 |
| GSE24585 | Up | 0.1579041824 |
| GSE37065 | Up | 0.1431751628 |
| GSE28863_A1 | Down | -0.0159543588 |
| GSE28863_A2 | Up | 0.1864560481 |
| GSE28863_A3 | Up | 0.0678556515 |
| GSE28863_A4 | Up | 0.0083887864 |
| GSE48662 | Up | 0.0757001722 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Compound | Target | Confidence score | Uniprot |
|---|---|---|---|
| CHEMBL1812066 | CHEMBL1795151 | 8 | P49789 |
| CHEMBL1812070 | CHEMBL1795151 | 8 | P49789 |
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenosine Monotungstate | DB02373 | EXPT00516 |
| Fructose | DB04173 | EXPT01495 |
| Ado-P-Ch2-P-Ps-Ado | DB04389 | EXPT01824 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-625-5p | MIMAT0003294 | MIRT006365 | Luciferase reporter assay | Functional MTI | 21711110 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT006364 | Luciferase reporter assay | Functional MTI | 21711110 |
| hsa-miR-143-3p | MIMAT0000435 | MIRT006362 | Luciferase reporter assay | Functional MTI | 21711110 |
| hsa-miR-217 | MIMAT0000274 | MIRT006363 | Luciferase reporter assay | Functional MTI | 21711110 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 10491433 | 2-specific YAC clone, located in the vicinity of the fragile histidine triad (FHIT) gene (but toward the telomere), that is capable of inducing sustained suppression of tumorigenicity in nude mice and of activating cellular senescence in vitro |
| 10491433 | CONCLUSION: These data provide strong evidence for the existence of a novel tumor suppressor locus adjacent to the previously identified candidate tumor suppressor gene, FHIT, in 3p14 |
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