HCSGD entry for FH
1. General information
| Official gene symbol | FH |
|---|---|
| Entrez ID | 2271 |
| Gene full name | fumarate hydratase |
| Other gene symbols | HLRCC LRCC MCL MCUL1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004333 | Fumarate hydratase activity | EXP | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006099 | Tricarboxylic acid cycle | IEA TAS | biological_process |
| GO:0006106 | Fumarate metabolic process | IEA | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045239 | Tricarboxylic acid cycle enzyme complex | IEA | cellular_component |
| GO:0048873 | Homeostasis of number of cells within a tissue | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9978800615 | 0.0051874929 | 0.9999902473 | 0.1460320856 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2426580803 |
| GSE13712_SHEAR | Down | -0.1101379945 |
| GSE13712_STATIC | Down | -0.1070943389 |
| GSE19018 | Down | -0.3488342561 |
| GSE19899_A1 | Down | -0.8733025544 |
| GSE19899_A2 | Down | -0.6107547325 |
| PubMed_21979375_A1 | Up | 0.2093166179 |
| PubMed_21979375_A2 | Down | -1.5524904663 |
| GSE35957 | Down | -0.1678004828 |
| GSE36640 | Down | -0.8087657007 |
| GSE54402 | Down | -0.0812139681 |
| GSE9593 | Down | -0.3302101053 |
| GSE43922 | Down | -0.4849030497 |
| GSE24585 | Down | -0.2188502338 |
| GSE37065 | Down | -0.3840684293 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.7853661811 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT047393 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25613188 | Mutations in the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase (FH) are associated with a highly malignant form of renal cancer |
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