HCSGD entry for FGR

1. General information

Official gene symbolFGR
Entrez ID2268
Gene full nameGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
Other gene symbolsSRC2 c-fgr c-src2 p55-Fgr p55c-fgr p58-Fgr p58c-fgr
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001784Phosphotyrosine bindingIEA ISSmolecular_function
GO:0002768Immune response-regulating cell surface receptor signaling pathwayTASbiological_process
GO:0004713Protein tyrosine kinase activityIDA IEAmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005743Mitochondrial inner membraneIEAcellular_component
GO:0005758Mitochondrial intermembrane spaceIEAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005856CytoskeletonIDAcellular_component
GO:0005886Plasma membraneISScellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0007229Integrin-mediated signaling pathwayIEA IMP ISSbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008360Regulation of cell shapeIEA ISSbiological_process
GO:0009615Response to virusTASbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIMPbiological_process
GO:0015629Actin cytoskeletonIEA ISScellular_component
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0019901Protein kinase bindingIEA ISSmolecular_function
GO:0030335Positive regulation of cell migrationIEA ISSbiological_process
GO:0032587Ruffle membraneIEA ISScellular_component
GO:0034987Immunoglobulin receptor bindingIEA ISSmolecular_function
GO:0034988Fc-gamma receptor I complex bindingIDAmolecular_function
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0043306Positive regulation of mast cell degranulationIEA ISSbiological_process
GO:0043552Positive regulation of phosphatidylinositol 3-kinase activityIMPbiological_process
GO:0045087Innate immune responseIEA TASbiological_process
GO:0045088Regulation of innate immune responseIEA ISSbiological_process
GO:0045859Regulation of protein kinase activityIEA ISSbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0050715Positive regulation of cytokine secretionIEA ISSbiological_process
GO:0050764Regulation of phagocytosisIEA ISSbiological_process
GO:0050830Defense response to Gram-positive bacteriumIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.76431120400.43192508260.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0283058370
GSE13712_SHEARDown-0.7357312890
GSE13712_STATICDown-0.2548268689
GSE19018Down-0.1056868038
GSE19899_A1Down-0.0647276037
GSE19899_A2Down-0.0364186645
PubMed_21979375_A1Up0.2280406788
PubMed_21979375_A2Up0.0923716520
GSE35957Up0.1033909133
GSE36640Up0.1192016938
GSE54402Up0.0378493807
GSE9593Down-0.0408655598
GSE43922Up0.0480791504
GSE24585Up0.0526248229
GSE37065Up0.0070035743
GSE28863_A1Down-0.2828138388
GSE28863_A2Down-0.0571817978
GSE28863_A3Up0.1864450989
GSE28863_A4Up0.1725537776
GSE48662Down-0.1122900083

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22339619OBJECTIVE: The aim of our study was to investigate the change of count and the status of cellular senescence in fetal endothelial progenitor cells (EPCs) obtained from the umbilical cord blood of women with fetal growth restriction (FGR)
22339619METHODS: Fetal EPCs were obtained from thirty five normal and thirty pregnant women with FGR
22339619RESULTS: Fetal EPC counts were significantly decreased in the FGR group compared with normal controls
22339619In the FGR group, the EPC differentiation time was prolonged, OEC colonies were much less formed, the staining intensity of SA-beta-gal was relatively increased and the telomerase activity of EPCs was significantly decreased, compared with normal pregnancy (p < 0
22339619CONCLUSIONS: The fetal EPCs in FGR pregnancies were decreased, functionally impaired and senescently altered
19359039A hallmark of fetal growth restriction (FGR) is restricted placental development and insufficient nutrient supply to the fetus
19359039It has previously been shown that activity levels of telomerase, the enzyme responsible for completing replication of telomeric DNA during cell division, is suppressed in FGR placenta samples as compared to control placenta samples from donors of the same gestational age
19359039Here we examine whether telomere length maintenance is also compromised in FGR placenta samples
19359039Southern analysis of telomere length for placenta and cord blood samples from 32 FGR and 36 control donors, ranging in gestational age from 37 to 40 weeks, revealed significantly shorter telomeres (P
19359039Furthermore, analysis of telomerase extracts, RNA and DNA placental samples from donors with and without idiopathic FGR confirmed a direct association between suppression of telomerase activity and reduced telomere length in FGR placenta
19359039These observations support a direct affect of reduced telomerase activity levels on the placental pathology associated with FGR
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