HCSGD entry for FGFR1
1. General information
| Official gene symbol | FGFR1 |
|---|---|
| Entrez ID | 2260 |
| Gene full name | fibroblast growth factor receptor 1 |
| Other gene symbols | BFGFR CD331 CEK FGFBR FGFR-1 FLG FLT-2 FLT2 HBGFR HH2 KAL2 N-SAM OGD bFGF-R-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000165 | MAPK cascade | TAS | biological_process |
| GO:0001501 | Skeletal system development | TAS | biological_process |
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0001657 | Ureteric bud development | IEA | biological_process |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001759 | Organ induction | IEA | biological_process |
| GO:0001764 | Neuron migration | TAS | biological_process |
| GO:0002053 | Positive regulation of mesenchymal cell proliferation | IEA | biological_process |
| GO:0002062 | Chondrocyte differentiation | IEA | biological_process |
| GO:0004713 | Protein tyrosine kinase activity | IDA | molecular_function |
| GO:0005007 | Fibroblast growth factor-activated receptor activity | IDA IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | NAS | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006468 | Protein phosphorylation | NAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007605 | Sensory perception of sound | IEA | biological_process |
| GO:0008201 | Heparin binding | IDA | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IDA IEA IGI IMP | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | IDA IGI IPI TAS | biological_process |
| GO:0010518 | Positive regulation of phospholipase activity | TAS | biological_process |
| GO:0010863 | Positive regulation of phospholipase C activity | IDA | biological_process |
| GO:0010976 | Positive regulation of neuron projection development | IEA | biological_process |
| GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA NAS | cellular_component |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0016477 | Cell migration | TAS | biological_process |
| GO:0017134 | Fibroblast growth factor binding | IDA | molecular_function |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IDA | biological_process |
| GO:0021847 | Ventricular zone neuroblast division | IEA | biological_process |
| GO:0030326 | Embryonic limb morphogenesis | IEA | biological_process |
| GO:0030901 | Midbrain development | IEA | biological_process |
| GO:0035607 | Fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development | IEA | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0042472 | Inner ear morphogenesis | IEA | biological_process |
| GO:0042473 | Outer ear morphogenesis | IEA | biological_process |
| GO:0042474 | Middle ear morphogenesis | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0043009 | Chordate embryonic development | TAS | biological_process |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0043406 | Positive regulation of MAP kinase activity | IDA | biological_process |
| GO:0043410 | Positive regulation of MAPK cascade | IMP | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045595 | Regulation of cell differentiation | TAS | biological_process |
| GO:0045666 | Positive regulation of neuron differentiation | IMP | biological_process |
| GO:0045787 | Positive regulation of cell cycle | IEA | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0048339 | Paraxial mesoderm development | IEA | biological_process |
| GO:0048378 | Regulation of lateral mesodermal cell fate specification | IEA | biological_process |
| GO:0048469 | Cell maturation | IEA | biological_process |
| GO:0048705 | Skeletal system morphogenesis | TAS | biological_process |
| GO:0048762 | Mesenchymal cell differentiation | IEA | biological_process |
| GO:0060045 | Positive regulation of cardiac muscle cell proliferation | IEA | biological_process |
| GO:0060117 | Auditory receptor cell development | IEA | biological_process |
| GO:0060173 | Limb development | IEA | biological_process |
| GO:0060445 | Branching involved in salivary gland morphogenesis | IEA | biological_process |
| GO:0060484 | Lung-associated mesenchyme development | IEA | biological_process |
| GO:0060665 | Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling | IEA | biological_process |
| GO:0090080 | Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway | IEA | biological_process |
| GO:2001239 | Regulation of extrinsic apoptotic signaling pathway in absence of ligand | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7908769614 | 0.0369899092 | 0.9999902473 | 0.3626113222 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1372023810 |
| GSE13712_SHEAR | Down | -0.3118002666 |
| GSE13712_STATIC | Down | -0.2642439539 |
| GSE19018 | Down | -0.1192230752 |
| GSE19899_A1 | Down | -0.5350868280 |
| GSE19899_A2 | Down | -0.6035842635 |
| PubMed_21979375_A1 | Down | -0.6793658860 |
| PubMed_21979375_A2 | Down | -0.2717809692 |
| GSE35957 | Down | -0.0656109963 |
| GSE36640 | Down | -0.0368276259 |
| GSE54402 | Down | -0.6927064864 |
| GSE9593 | Up | 0.2798330385 |
| GSE43922 | Down | -0.7486167501 |
| GSE24585 | Down | -0.4542764335 |
| GSE37065 | Up | 0.1654555704 |
| GSE28863_A1 | Up | 0.4566769783 |
| GSE28863_A2 | Up | 0.6677226552 |
| GSE28863_A3 | Down | -0.1750497189 |
| GSE28863_A4 | Up | 0.0250603682 |
| GSE48662 | Up | 0.4565878704 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Palifermin | DB00039 | BTD00042 | BIOD00042 |
| Sorafenib | DB00398 | APRD01304 | DB07438 |
| SU4984 | DB02058 | EXPT02973 |
| XL999 | DB05014 | - |
| 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine | DB07525 | - |
| (E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol | DB07840 | - |
| 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE | DB08577 | - |
| Regorafenib | DB08896 | - |
| Ponatinib | DB08901 | - |
| Lenvatinib | DB09078 | - |
| Nintedanib | DB09079 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-424-5p | MIMAT0001341 | MIRT003228 | Luciferase reporter assay | Functional MTI | 20065103 |
| hsa-miR-133b | MIMAT0000770 | MIRT007113 | Luciferase reporter assay//Western blot//Immunohistochemistry//qRT-PCR | Functional MTI | 23296701 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022300 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037725 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038377 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047295 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047650 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-424-5p | MIMAT0001341 | NA | hsa-miR-424 | 20065103 | |||
| hsa-miR-16-5p | MIMAT0000069 | 1 | hsa-miR-16 | {Western blot} | {overexpression by miRNA mimics tranfection} | 21885851 | |
| hsa-miR-16-5p | MIMAT0000069 | 2 | hsa-miR-16 | {Western blot} | {overexpression by miRNA mimics tranfection} | 21885851 | |
| hsa-miR-424-5p | MIMAT0001341 | NA | hsa-miR-424 | {Western blot} | {overexpression by miRNA mimics tranfection} | 21885851 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26250908 | The determination of the activation of receptors such as FGFR1, Met, and insulin growth factor 1 receptor beta indicated that the augmented FGFR1/AKT signaling was specifically involved in premature senescence in a HS-dependent manner |
| 26250908 | Thus, blockade of either FGFR1 or AKT prohibited p53 and p21 accumulation and cell fate switched from cellular senescence to apoptosis |
| 26250908 | In particular, desulfation at the 2-O position in the HS chain contributed to the premature senescence via the augmented FGFR1 signaling |
| 21527526 | We show here that FGFR1/2 are expressed by rare mesenchymal progenitors in putative MSC niches in vivo, including the perichondrium, periosteum, and trabecular marrow |
| 21527526 | In summary, FGFR1/2 are developmentally regulated markers of MSCs in vivo and in vitro and are important in maintaining MSC stemness |
| 8972724 | The human diploid fibroblast senescence pathway is independent of interleukin-1 alpha mRNA levels and tyrosine phosphorylation of FGFR-1 substrates |
| 8707855 | FGF-1-dependent proliferative and migratory responses are impaired in senescent human umbilical vein endothelial cells and correlate with the inability to signal tyrosine phosphorylation of fibroblast growth factor receptor-1 substrates |
| 8707855 | However, the tyrosine phosphorylation of FGFR-1 substrates, Src and cortactin, is impaired in senescent HUVEC, and only the presenescent cell populations exhibit a FGF-1-dependent Src tyrosine kinase activity |
| 8707855 | These data suggest that the induction of gene expression is insufficient to promote a proliferative or migratory phenotype in senescent HUVEC and that the attenuation of the FGFR-1 signal transduction pathway may be involved in the inability of senescent HUVEC to proliferate and/or migrate |
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