HCSGD entry for FGF4

1. General information

Official gene symbolFGF4
Entrez ID2249
Gene full namefibroblast growth factor 4
Other gene symbolsHBGF-4 HST HST-1 HSTF1 K-FGF KFGF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001502Cartilage condensationIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIEAbiological_process
GO:0005104Fibroblast growth factor receptor bindingIEAmolecular_function
GO:0005575Cellular_componentNDcellular_component
GO:0005576Extracellular regionTAScellular_component
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0007067MitosisNASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008083Growth factor activityIEA NASmolecular_function
GO:0008201Heparin bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIGIbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayIGI TASbiological_process
GO:0010463Mesenchymal cell proliferationIDAbiological_process
GO:0019827Stem cell maintenanceIEAbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0060363Cranial suture morphogenesisIEAbiological_process
GO:0060561Apoptotic process involved in morphogenesisIEAbiological_process
GO:0060591Chondroblast differentiationIDAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.34128748530.93493108160.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0777714536
GSE13712_SHEARDown-0.0535462292
GSE13712_STATICDown-0.2176497592
GSE19018Up0.1045956803
GSE19899_A1Up0.1074002102
GSE19899_A2Up0.1541484853
PubMed_21979375_A1Down-0.0252114760
PubMed_21979375_A2Down-0.0302490390
GSE35957Up0.1639032407
GSE36640Up0.0145829890
GSE54402Down-0.0457183710
GSE9593Up0.0907710930
GSE43922Up0.1404483489
GSE24585Up0.6300867798
GSE37065Down-0.0152728802
GSE28863_A1Down-0.1004455970
GSE28863_A2Up0.0181003419
GSE28863_A3Up0.3107254264
GSE28863_A4Up0.0726593224
GSE48662Up0.1506216092

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Pentosan PolysulfateDB00686 APRD01175
TP-508DB05309 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018466MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24491556We found that expression of EGF, FGF-4 and HGF were down-regulated during serial passage of bone marrow-derived mesenchymal stem cells (BMSCs)
24491556But FGF-2 and FGF-4 suppressed LC3-II expression and down-regulated senescent cells during long-term (i
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