HCSGD entry for FGA
1. General information
| Official gene symbol | FGA |
|---|---|
| Entrez ID | 2243 |
| Gene full name | fibrinogen alpha chain |
| Other gene symbols | Fib2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0005102 | Receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | NAS TAS | cellular_component |
| GO:0005577 | Fibrinogen complex | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005938 | Cell cortex | IEA | cellular_component |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0009897 | External side of plasma membrane | IDA | cellular_component |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030674 | Protein binding, bridging | IEA | molecular_function |
| GO:0031091 | Platelet alpha granule | IDA | cellular_component |
| GO:0031093 | Platelet alpha granule lumen | TAS | cellular_component |
| GO:0051258 | Protein polymerization | IEA | biological_process |
| GO:0051592 | Response to calcium ion | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8105258653 | 0.8171541811 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0227685148 |
| GSE13712_SHEAR | Down | -0.1494480694 |
| GSE13712_STATIC | Up | 0.0782133025 |
| GSE19018 | Up | 0.1227761656 |
| GSE19899_A1 | Up | 0.1376131157 |
| GSE19899_A2 | Down | -0.0433451283 |
| PubMed_21979375_A1 | Up | 0.1104461181 |
| PubMed_21979375_A2 | Down | -0.0553721342 |
| GSE35957 | Up | 0.0258762555 |
| GSE36640 | Up | 0.0458923937 |
| GSE54402 | Down | -0.0045136377 |
| GSE9593 | Down | -0.0165978515 |
| GSE43922 | Up | 0.0174332408 |
| GSE24585 | Down | -0.0029459353 |
| GSE37065 | Down | -0.0409703234 |
| GSE28863_A1 | Up | 0.0189837162 |
| GSE28863_A2 | Down | -0.0401502791 |
| GSE28863_A3 | Up | 0.1175674713 |
| GSE28863_A4 | Down | -0.0216094784 |
| GSE48662 | Up | 0.0157164738 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Alteplase | DB00009 | BTD00050 | BIOD00050 |
| Reteplase | DB00015 | BTD00013 | BIOD00013 |
| Anistreplase | DB00029 | BTD00102 | BIOD00102 |
| Tenecteplase | DB00031 | BTD00019 | BIOD00019 |
| Sucralfate | DB00364 | APRD01238 |
| Alfimeprase | DB04919 | - |
| Ancrod | DB05099 | - |
| EP-2104R | DB05675 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-409-3p | MIMAT0001639 | MIRT005518 | ELISA//Flow//Luciferase reporter assay | Non-Functional MTI | 20570858 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT005527 | Luciferase reporter assay | Functional MTI | 20570858 |
| hsa-miR-144-3p | MIMAT0000436 | MIRT005529 | Luciferase reporter assay | Non-Functional MTI | 20570858 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT005531 | Luciferase reporter assay | Functional MTI | 20570858 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT005533 | Luciferase reporter assay | Functional MTI | 20570858 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
