HCSGD entry for FER

1. General information

Official gene symbolFER
Entrez ID2241
Gene full namefer (fps/fes related) tyrosine kinase
Other gene symbolsFerT PPP1R74 TYK3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000226Microtubule cytoskeleton organizationIMPbiological_process
GO:0000278Mitotic cell cycleIMPbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0001932Regulation of protein phosphorylationISSbiological_process
GO:0003779Actin bindingIEAmolecular_function
GO:0004713Protein tyrosine kinase activityIEA TASmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIDAmolecular_function
GO:0005154Epidermal growth factor receptor bindingIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0006935ChemotaxisIEAbiological_process
GO:0008157Protein phosphatase 1 bindingIEAmolecular_function
GO:0008283Cell proliferationIEA IMPbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0008289Lipid bindingIDAmolecular_function
GO:0010591Regulation of lamellipodium assemblyIDAbiological_process
GO:0010762Regulation of fibroblast migrationIEAbiological_process
GO:0015629Actin cytoskeletonIDAcellular_component
GO:0015630Microtubule cytoskeletonIDAcellular_component
GO:0017137Rab GTPase bindingIEAmolecular_function
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0019221Cytokine-mediated signaling pathwayIMPbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0030027LamellipodiumIDAcellular_component
GO:0030054Cell junctionIDAcellular_component
GO:0030335Positive regulation of cell migrationIEA IMPbiological_process
GO:0030838Positive regulation of actin filament polymerizationIMPbiological_process
GO:0031234Extrinsic component of cytoplasmic side of plasma membraneIDAcellular_component
GO:0031532Actin cytoskeleton reorganizationIEA ISSbiological_process
GO:0032496Response to lipopolysaccharideISSbiological_process
GO:0032869Cellular response to insulin stimulusISSbiological_process
GO:0033007Negative regulation of mast cell activation involved in immune responseISSbiological_process
GO:0034446Substrate adhesion-dependent cell spreadingISSbiological_process
GO:0034614Cellular response to reactive oxygen speciesISSbiological_process
GO:0035426Extracellular matrix-cell signalingISSbiological_process
GO:0035556Intracellular signal transductionTASbiological_process
GO:0036006Cellular response to macrophage colony-stimulating factor stimulusIMPbiological_process
GO:0036119Response to platelet-derived growth factorISSbiological_process
GO:0038028Insulin receptor signaling pathway via phosphatidylinositol 3-kinaseISSbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayISSbiological_process
GO:0038109Kit signaling pathwayISSbiological_process
GO:0042058Regulation of epidermal growth factor receptor signaling pathwayIEA IMPbiological_process
GO:0042503Tyrosine phosphorylation of Stat3 proteinIDAbiological_process
GO:0044331Cell-cell adhesion mediated by cadherinISSbiological_process
GO:0045295Gamma-catenin bindingIEAmolecular_function
GO:0045296Cadherin bindingIEAmolecular_function
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0048008Platelet-derived growth factor receptor signaling pathwayISS TASbiological_process
GO:0050904DiapedesisISSbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIEA IMPbiological_process
GO:0070102Interleukin-6-mediated signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.71272416320.03291733600.99999024730.3423220861

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.8171040743
GSE13712_SHEARDown-0.1804432637
GSE13712_STATICDown-0.1777342841
GSE19018Up0.1006673522
GSE19899_A1Down-0.1752701757
GSE19899_A2Down-1.0986968683
PubMed_21979375_A1Down-0.0725797778
PubMed_21979375_A2Down-0.7906666487
GSE35957Up0.3513443336
GSE36640Down-0.4125552079
GSE54402Up0.1024619351
GSE9593Down-0.2066312464
GSE43922Down-0.3816775579
GSE24585Up0.2767846413
GSE37065Up0.0794106164
GSE28863_A1Up0.3346838712
GSE28863_A2Up0.4686888633
GSE28863_A3Down-0.4849846843
GSE28863_A4Down-0.4921406859
GSE48662Up0.2387868405

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26a-2-3pMIMAT0004681MIRT038279CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050063CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT051027CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.