HCSGD entry for FECH

1. General information

Official gene symbolFECH
Entrez ID2235
Gene full nameferrochelatase
Other gene symbolsEPP FCE
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004325Ferrochelatase activityIDA IEA TASmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005743Mitochondrial inner membraneIEAcellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0006091Generation of precursor metabolites and energyTASbiological_process
GO:0006778Porphyrin-containing compound metabolic processTASbiological_process
GO:0006783Heme biosynthetic processIEA TASbiological_process
GO:0008198Ferrous iron bindingTASmolecular_function
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0009416Response to light stimulusTASbiological_process
GO:0009589Detection of UVIEAbiological_process
GO:0010288Response to lead ionIEAbiological_process
GO:0010999Regulation of eIF2 alpha phosphorylation by hemeIEAbiological_process
GO:0017085Response to insecticideIEAbiological_process
GO:0020037Heme bindingIEAmolecular_function
GO:0030218Erythrocyte differentiationIEAbiological_process
GO:0030350Iron-responsive element bindingIEAmolecular_function
GO:0034379Very-low-density lipoprotein particle assemblyIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0046501Protoporphyrinogen IX metabolic processIDA IEAbiological_process
GO:0046685Response to arsenic-containing substanceIEAbiological_process
GO:0046984Regulation of hemoglobin biosynthetic processIEAbiological_process
GO:00515372 iron, 2 sulfur cluster bindingIEAmolecular_function
GO:0051597Response to methylmercuryIEAbiological_process
GO:0055072Iron ion homeostasisIEAbiological_process
GO:0070541Response to platinum ionIEAbiological_process
GO:0071549Cellular response to dexamethasone stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98942547780.00971812240.99999024730.1951111365

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2618220339
GSE13712_SHEARDown-0.1911300756
GSE13712_STATICDown-0.1931425287
GSE19018Down-0.1340998299
GSE19899_A1Down-0.5753306044
GSE19899_A2Down-1.0895162765
PubMed_21979375_A1Down-1.5972390010
PubMed_21979375_A2Down-0.8046854294
GSE35957Up0.2166889330
GSE36640Down-0.1383334452
GSE54402Down-0.7669234590
GSE9593Up0.0224884440
GSE43922Down-0.8936965716
GSE24585Down-0.0059934220
GSE37065Down-0.2927160428
GSE28863_A1Up0.1204634791
GSE28863_A2Down-0.0113715145
GSE28863_A3Down-0.4901781995
GSE28863_A4Up0.1120825385
GSE48662Down-0.1095724402

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Cholic AcidDB02659 EXPT00906
Cholic AcidDB02659 EXPT00906

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022695MicroarrayFunctional MTI (Weak)18668037
hsa-miR-1301-3pMIMAT0005797MIRT036042CLASHFunctional MTI (Weak)23622248
hsa-miR-25-3pMIMAT0000081MIRT050277CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051219CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.