HCSGD entry for KDM1B
1. General information
| Official gene symbol | KDM1B |
|---|---|
| Entrez ID | 221656 |
| Gene full name | lysine (K)-specific demethylase 1B |
| Other gene symbols | AOF1 C6orf193 LSD2 bA204B7.3 dJ298J15.2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0006349 | Regulation of gene expression by genetic imprinting | ISS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0034648 | Histone demethylase activity (H3-dimethyl-K4 specific) | ISS | molecular_function |
| GO:0034649 | Histone demethylase activity (H3-monomethyl-K4 specific) | ISS | molecular_function |
| GO:0034720 | Histone H3-K4 demethylation | ISS | biological_process |
| GO:0043046 | DNA methylation involved in gamete generation | IEA | biological_process |
| GO:0044030 | Regulation of DNA methylation | ISS | biological_process |
| GO:0050660 | Flavin adenine dinucleotide binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0555846396 | 0.9378017515 | 0.5138894626 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0527660862 |
| GSE13712_SHEAR | Up | 0.3326298813 |
| GSE13712_STATIC | Up | 0.5101433764 |
| GSE19018 | Up | 0.0453090110 |
| GSE19899_A1 | Up | 0.1187017330 |
| GSE19899_A2 | Up | 0.5534363169 |
| PubMed_21979375_A1 | Down | -0.3238764686 |
| PubMed_21979375_A2 | Up | 0.0729325706 |
| GSE35957 | Up | 1.3169382179 |
| GSE36640 | Up | 0.3775056521 |
| GSE54402 | Down | -0.1011735213 |
| GSE9593 | Down | -0.1607267135 |
| GSE43922 | Up | 0.1439747953 |
| GSE24585 | Up | 0.2268376837 |
| GSE37065 | Up | 0.1242752572 |
| GSE28863_A1 | Down | -0.2388715623 |
| GSE28863_A2 | Up | 0.2388897918 |
| GSE28863_A3 | Up | 0.2176262600 |
| GSE28863_A4 | Up | 0.0635697542 |
| GSE48662 | Down | -0.1511476608 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | MIRT002552 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019487 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026955 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
