HCSGD entry for MARCH8
1. General information
| Official gene symbol | MARCH8 |
|---|---|
| Entrez ID | 220972 |
| Gene full name | membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase |
| Other gene symbols | MARCH-VIII MIR RNF178 c-MIR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0002495 | Antigen processing and presentation of peptide antigen via MHC class II | IEA | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005764 | Lysosome | IDA | cellular_component |
| GO:0005765 | Lysosomal membrane | IEA | cellular_component |
| GO:0005768 | Endosome | IDA | cellular_component |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030659 | Cytoplasmic vesicle membrane | IEA | cellular_component |
| GO:0031901 | Early endosome membrane | IEA | cellular_component |
| GO:0042289 | MHC class II protein binding | IEA | molecular_function |
| GO:0045347 | Negative regulation of MHC class II biosynthetic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9166213252 | 0.0718076973 | 0.9999902473 | 0.5049092800 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0572593378 |
| GSE13712_SHEAR | Down | -0.4456689041 |
| GSE13712_STATIC | Down | -0.3126350714 |
| GSE19018 | Up | 0.4067439812 |
| GSE19899_A1 | Down | -0.2114145155 |
| GSE19899_A2 | Down | -0.1959426232 |
| PubMed_21979375_A1 | Down | -0.6491951464 |
| PubMed_21979375_A2 | Down | -0.1826454276 |
| GSE35957 | Up | 0.3598140503 |
| GSE36640 | Down | -0.1230857432 |
| GSE54402 | Down | -0.3805557435 |
| GSE9593 | Up | 0.4083331662 |
| GSE43922 | Down | -0.8806198950 |
| GSE24585 | Up | 0.1471932578 |
| GSE37065 | Down | -0.0912819525 |
| GSE28863_A1 | Up | 0.0316986742 |
| GSE28863_A2 | Up | 0.0309042788 |
| GSE28863_A3 | Down | -0.6127869908 |
| GSE28863_A4 | Down | -0.1209621885 |
| GSE48662 | Up | 0.1340925706 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017780 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
