HCSGD entry for FBN2
1. General information
| Official gene symbol | FBN2 |
|---|---|
| Entrez ID | 2201 |
| Gene full name | fibrillin 2 |
| Other gene symbols | CCA DA9 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001527 | Microfibril | TAS | cellular_component |
| GO:0005201 | Extracellular matrix structural constituent | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005578 | Proteinaceous extracellular matrix | IEA TAS | cellular_component |
| GO:0009653 | Anatomical structure morphogenesis | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030326 | Embryonic limb morphogenesis | IEA | biological_process |
| GO:0030501 | Positive regulation of bone mineralization | ISS | biological_process |
| GO:0035583 | Sequestering of TGFbeta in extracellular matrix | ISS | biological_process |
| GO:0045669 | Positive regulation of osteoblast differentiation | ISS | biological_process |
| GO:0060346 | Bone trabecula formation | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2739304624 | 0.0062985715 | 0.9702724031 | 0.1617048591 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0113191709 |
| GSE13712_SHEAR | Up | 0.1771359487 |
| GSE13712_STATIC | Up | 0.2434563083 |
| GSE19018 | Down | -1.1997176405 |
| GSE19899_A1 | Down | -0.4009793505 |
| GSE19899_A2 | Down | -0.6273532406 |
| PubMed_21979375_A1 | Down | -0.9292405070 |
| PubMed_21979375_A2 | Down | -0.4049409403 |
| GSE35957 | Up | 0.1766317222 |
| GSE36640 | Down | -1.0835380557 |
| GSE54402 | Down | -1.0371900937 |
| GSE9593 | Up | 0.3946736654 |
| GSE43922 | Down | -1.0745630526 |
| GSE24585 | Down | -0.3497252091 |
| GSE37065 | Down | -0.4183030231 |
| GSE28863_A1 | Up | 1.2972650350 |
| GSE28863_A2 | Up | 1.1087902425 |
| GSE28863_A3 | Up | 0.2357500195 |
| GSE28863_A4 | Up | 0.0261432360 |
| GSE48662 | Down | -0.9126941265 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-101-3p | MIMAT0000099 | MIRT004012 | Western blot | Non-Functional MTI | 19008416 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017958 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021389 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037707 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040044 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040660 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045540 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30d-5p | MIMAT0000245 | MIRT047815 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | NA | hsa-miR-204 | 20369013 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
