HCSGD entry for TPCN2
1. General information
| Official gene symbol | TPCN2 |
|---|---|
| Entrez ID | 219931 |
| Gene full name | two pore segment channel 2 |
| Other gene symbols | SHEP10 TPC2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005216 | Ion channel activity | IEA | molecular_function |
| GO:0005245 | Voltage-gated calcium channel activity | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA TAS | cellular_component |
| GO:0006874 | Cellular calcium ion homeostasis | IDA | biological_process |
| GO:0006939 | Smooth muscle contraction | ISS | biological_process |
| GO:0010008 | Endosome membrane | IDA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0051209 | Release of sequestered calcium ion into cytosol | IEA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0072345 | NAADP-sensitive calcium-release channel activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6646325785 | 0.6275545762 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0458516473 |
| GSE13712_SHEAR | Up | 0.1278845131 |
| GSE13712_STATIC | Up | 0.3770133890 |
| GSE19018 | Down | -0.0977043876 |
| GSE19899_A1 | Down | -0.0073353351 |
| GSE19899_A2 | Down | -0.0448504297 |
| PubMed_21979375_A1 | Down | -0.0042701893 |
| PubMed_21979375_A2 | Up | 0.0982273623 |
| GSE35957 | Up | 0.0118489218 |
| GSE36640 | Up | 0.1103674202 |
| GSE54402 | Down | -0.3256607451 |
| GSE9593 | Down | -0.1098392048 |
| GSE43922 | Up | 0.0389916805 |
| GSE24585 | Down | -0.1263149022 |
| GSE37065 | Up | 0.0550590034 |
| GSE28863_A1 | Up | 0.1896805873 |
| GSE28863_A2 | Up | 0.3531934925 |
| GSE28863_A3 | Down | -0.1170293921 |
| GSE28863_A4 | Down | -0.0620577088 |
| GSE48662 | Down | -0.1011047892 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022968 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
