HCSGD entry for FASN

1. General information

Official gene symbolFASN
Entrez ID2194
Gene full namefatty acid synthase
Other gene symbolsFAS OA-519 SDR27X1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004312Fatty acid synthase activityTASmolecular_function
GO:0004313[acyl-carrier-protein] S-acetyltransferase activityIEAmolecular_function
GO:0004314[acyl-carrier-protein] S-malonyltransferase activityIEAmolecular_function
GO:00043153-oxoacyl-[acyl-carrier-protein] synthase activityIEAmolecular_function
GO:00043163-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activityIEAmolecular_function
GO:00043173-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activityIEAmolecular_function
GO:0004319Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activityIEAmolecular_function
GO:0004320Oleoyl-[acyl-carrier-protein] hydrolase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006084Acetyl-CoA metabolic processIEAbiological_process
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006631Fatty acid metabolic processTASbiological_process
GO:0006633Fatty acid biosynthetic processIEAbiological_process
GO:0006766Vitamin metabolic processTASbiological_process
GO:0006767Water-soluble vitamin metabolic processTASbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0015939Pantothenate metabolic processTASbiological_process
GO:0016295Myristoyl-[acyl-carrier-protein] hydrolase activityIEAmolecular_function
GO:0016296Palmitoyl-[acyl-carrier-protein] hydrolase activityIEAmolecular_function
GO:0019432Triglyceride biosynthetic processTASbiological_process
GO:0031325Positive regulation of cellular metabolic processTASbiological_process
GO:0035338Long-chain fatty-acyl-CoA biosynthetic processTASbiological_process
GO:0042470MelanosomeIEAcellular_component
GO:0042587Glycogen granuleIEAcellular_component
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0047117Enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activityIEAmolecular_function
GO:00474513-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activityIEAmolecular_function
GO:0070402NADPH bindingIEAmolecular_function
GO:0071353Cellular response to interleukin-4IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01704099770.92972932640.32240071381.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1789112982
GSE13712_SHEARUp0.1905373567
GSE13712_STATICUp0.0615932954
GSE19018Up0.0584593476
GSE19899_A1Up0.1099637576
GSE19899_A2Up0.6347863519
PubMed_21979375_A1Down-0.0143273441
PubMed_21979375_A2Up1.1662518256
GSE35957Down-0.0292810514
GSE36640Up0.1151337811
GSE54402Up0.3156276978
GSE9593Down-0.3688356698
GSE43922Up0.1414287024
GSE24585Up1.1711299211
GSE37065Down-0.3985932409
GSE28863_A1Up0.4146892859
GSE28863_A2Up0.7858323190
GSE28863_A3Up0.1875158436
GSE28863_A4Down-0.0488117822
GSE48662Down-0.0642416753

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL209656CHEMBL41589P49327
CHEMBL214037CHEMBL41589P49327
CHEMBL375390CHEMBL41589P49327
CHEMBL380035CHEMBL41589P49327
CHEMBL376206CHEMBL41589P49327
CHEMBL215910CHEMBL41589P49327
CHEMBL413773CHEMBL41589P49327
CHEMBL213458CHEMBL41589P49327
CHEMBL213635CHEMBL41589P49327
CHEMBL373985CHEMBL41589P49327
CHEMBL385709CHEMBL41589P49327
CHEMBL213583CHEMBL41589P49327
CHEMBL213299CHEMBL41589P49327
CHEMBL377865CHEMBL41589P49327
CHEMBL213634CHEMBL41589P49327
CHEMBL1834187CHEMBL41589P49327
CHEMBL1834198CHEMBL41589P49327
CHEMBL1834195CHEMBL41589P49327
CHEMBL1834194CHEMBL41589P49327
CHEMBL1834196CHEMBL41589P49327
CHEMBL439501CHEMBL41589P49327
CHEMBL213384CHEMBL41589P49327
CHEMBL1834184CHEMBL41589P49327
CHEMBL1834197CHEMBL41589P49327
CHEMBL1834190CHEMBL41589P49327
CHEMBL1834192CHEMBL41589P49327
CHEMBL1834186CHEMBL41589P49327
CHEMBL1834180CHEMBL41589P49327
CHEMBL1834182CHEMBL41589P49327
CHEMBL213124CHEMBL41589P49327
CHEMBL1834178CHEMBL41589P49327
CHEMBL1834191CHEMBL41589P49327
CHEMBL1834045CHEMBL41589P49327
CHEMBL1834185CHEMBL41589P49327
CHEMBL45627CHEMBL41589P49327
CHEMBL1834179CHEMBL41589P49327
CHEMBL1834193CHEMBL41589P49327
CHEMBL213433CHEMBL41589P49327
CHEMBL377474CHEMBL41589P49327
CHEMBL424703CHEMBL41589P49327
CHEMBL214119CHEMBL41589P49327
CHEMBL1834183CHEMBL41589P49327
CHEMBL1834044CHEMBL41589P49327
CHEMBL45627CHEMBL41589P49327
CHEMBL399043CHEMBL41589P49327
CHEMBL214860CHEMBL41589P49327
CHEMBL213968CHEMBL41589P49327
CHEMBL214690CHEMBL41589P49327
CHEMBL1834188CHEMBL41589P49327
CHEMBL151CHEMBL41589P49327
CHEMBL1834189CHEMBL41589P49327
CHEMBL361025CHEMBL41588P49327
CHEMBL561643CHEMBL41588P49327
CHEMBL323197CHEMBL41588P49327
CHEMBL297453CHEMBL41588P49327
CHEMBL1257642CHEMBL41588P49327
CHEMBL260553CHEMBL41588P49327
CHEMBL1256380CHEMBL41588P49327
CHEMBL470981CHEMBL41588P49327
CHEMBL187265CHEMBL41588P49327
CHEMBL454580CHEMBL41588P49327
CHEMBL1256379CHEMBL41588P49327
CHEMBL261706CHEMBL41588P49327
CHEMBL46624CHEMBL41584P49327
CHEMBL47994CHEMBL41584P49327
CHEMBL46902CHEMBL41584P49327
CHEMBL434775CHEMBL41584P49327
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  • Drugs

Name

Drug

Accession number

CeruleninDB01034 APRD00703
OrlistatDB01083 APRD00255

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-2110MIMAT0010133MIRT035759CLASHFunctional MTI (Weak)23622248
hsa-miR-1268aMIMAT0005922MIRT035847CLASHFunctional MTI (Weak)23622248
hsa-miR-1303MIMAT0005891MIRT035891CLASHFunctional MTI (Weak)23622248
hsa-miR-942-5pMIMAT0004985MIRT036557CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT036832CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037647CLASHFunctional MTI (Weak)23622248
hsa-miR-130b-5pMIMAT0004680MIRT038318CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039824CLASHFunctional MTI (Weak)23622248
hsa-miR-92b-3pMIMAT0003218MIRT040657CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041353CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041844CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042639CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042890CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043370CLASHFunctional MTI (Weak)23622248
hsa-miR-326MIMAT0000756MIRT043627CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT044920CLASHFunctional MTI (Weak)23622248
hsa-miR-27b-3pMIMAT0000419MIRT046177CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046667CLASHFunctional MTI (Weak)23622248
hsa-miR-10b-5pMIMAT0000254MIRT047454CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047715CLASHFunctional MTI (Weak)23622248
hsa-miR-197-3pMIMAT0000227MIRT048070CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048815CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049363CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050182CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050921CLASHFunctional MTI (Weak)23622248
hsa-miR-15a-5pMIMAT0000068MIRT051341CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-21-5pMIMAT0000076NAhsa-miR-2117991735
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24396695Finally, blocking lipogenesis with fatty acid synthase inhibitors (cerulenin and C75) and siRNA-mediated silencing of SREBP1 and ATP citrate lyase (ACL) significantly attenuated GSK3 inhibition-induced senescence
20431990The switching on of p53 also causes changes in fatty acid metabolism, especially down-regulation of both fatty acid synthase and stearoyl-CoA (delta-9) desaturase
19059270KEY FINDINGS: The levels of fatty acid synthase and stearoyl-CoA desaturase-1 and, consequently, the formation of monounsaturated fatty acids, were notably decreased in senescent cells when compared to proliferating (young) fibroblasts
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