HCSGD entry for FAH
1. General information
| Official gene symbol | FAH |
|---|---|
| Entrez ID | 2184 |
| Gene full name | fumarylacetoacetate hydrolase (fumarylacetoacetase) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004334 | Fumarylacetoacetase activity | EXP IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006527 | Arginine catabolic process | IEA | biological_process |
| GO:0006559 | L-phenylalanine catabolic process | IEA TAS | biological_process |
| GO:0006572 | Tyrosine catabolic process | IEA | biological_process |
| GO:0009072 | Aromatic amino acid family metabolic process | IEA | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0354492914 | 0.6152145625 | 0.4291908004 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0130367828 |
| GSE13712_SHEAR | Up | 0.7324671333 |
| GSE13712_STATIC | Up | 0.6256305145 |
| GSE19018 | Down | -0.0507940210 |
| GSE19899_A1 | Up | 0.5150253870 |
| GSE19899_A2 | Up | 0.9655415065 |
| PubMed_21979375_A1 | Up | 0.9727064256 |
| PubMed_21979375_A2 | Up | 0.6159199481 |
| GSE35957 | Down | -0.1354192358 |
| GSE36640 | Down | -0.1465934097 |
| GSE54402 | Up | 1.5767685252 |
| GSE9593 | Down | -0.0203780362 |
| GSE43922 | Down | -0.3068987936 |
| GSE24585 | Down | -0.2269122535 |
| GSE37065 | Up | 0.0258524509 |
| GSE28863_A1 | Down | -0.0503963191 |
| GSE28863_A2 | Down | -0.1110622424 |
| GSE28863_A3 | Down | -0.7320885385 |
| GSE28863_A4 | Up | 0.0335610807 |
| GSE48662 | Down | -0.0379635112 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Fumarate | DB01677 | EXPT01460 | EXPT01511 |
| Acetoacetic Acid | DB01762 | EXPT00381 | DB04025 |
| 4-[Hydroxy-[Methyl-Phosphinoyl]]-3-Oxo-Butanoic Acid | DB01832 | EXPT01703 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019924 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025492 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030485 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048789 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
