HCSGD entry for FANCC
1. General information
| Official gene symbol | FANCC |
|---|---|
| Entrez ID | 2176 |
| Gene full name | Fanconi anemia, complementation group C |
| Other gene symbols | FA3 FAC FACC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002262 | Myeloid cell homeostasis | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006289 | Nucleotide-excision repair | IEA | biological_process |
| GO:0006461 | Protein complex assembly | TAS | biological_process |
| GO:0007281 | Germ cell development | IEA | biological_process |
| GO:0019430 | Removal of superoxide radicals | IEA | biological_process |
| GO:0043240 | Fanconi anaemia nuclear complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8730978610 | 0.1345204551 | 0.9999902473 | 0.7068702136 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0270664680 |
| GSE13712_SHEAR | Up | 0.0628672690 |
| GSE13712_STATIC | Down | -0.0951777067 |
| GSE19018 | Down | -0.0516910102 |
| GSE19899_A1 | Down | -0.1035988462 |
| GSE19899_A2 | Down | -0.1392877039 |
| PubMed_21979375_A1 | Down | -0.3921401201 |
| PubMed_21979375_A2 | Down | -0.3291347525 |
| GSE35957 | Down | -0.0127029895 |
| GSE36640 | Down | -0.1278418153 |
| GSE54402 | Down | -0.0290962549 |
| GSE9593 | Down | -0.1321134625 |
| GSE43922 | Down | -0.4511608059 |
| GSE24585 | Up | 0.4781721410 |
| GSE37065 | Up | 0.0264751503 |
| GSE28863_A1 | Up | 0.4422576125 |
| GSE28863_A2 | Down | -0.1955466123 |
| GSE28863_A3 | Down | -0.3265613108 |
| GSE28863_A4 | Up | 0.0138114742 |
| GSE48662 | Down | -0.3693817869 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029075 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046532 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15769896 | Taken together, these results suggest that reoxygenation induces premature senescence in Fancc-/- BM hematopoietic cells by signaling through p53, up-regulating p21, and causing senescent cell-cycle arrest |
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