HCSGD entry for ALDH2
1. General information
| Official gene symbol | ALDH2 |
|---|---|
| Entrez ID | 217 |
| Gene full name | aldehyde dehydrogenase 2 family (mitochondrial) |
| Other gene symbols | ALDH-E2 ALDHI ALDM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004029 | Aldehyde dehydrogenase (NAD) activity | EXP | molecular_function |
| GO:0004030 | Aldehyde dehydrogenase [NAD(P)+] activity | TAS | molecular_function |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006066 | Alcohol metabolic process | TAS | biological_process |
| GO:0006068 | Ethanol catabolic process | IEA | biological_process |
| GO:0006069 | Ethanol oxidation | TAS | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0009055 | Electron carrier activity | TAS | molecular_function |
| GO:0016620 | Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | IEA | molecular_function |
| GO:0042136 | Neurotransmitter biosynthetic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4868970936 | 0.0015822005 | 0.9999902473 | 0.0765534926 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6224542078 |
| GSE13712_SHEAR | Down | -0.5396646766 |
| GSE13712_STATIC | Down | -0.3248629589 |
| GSE19018 | Down | -0.8404130963 |
| GSE19899_A1 | Down | -1.7062386632 |
| GSE19899_A2 | Down | -1.0162331142 |
| PubMed_21979375_A1 | Down | -2.6305945116 |
| PubMed_21979375_A2 | Down | -1.7757094911 |
| GSE35957 | Down | -1.0821311453 |
| GSE36640 | Up | 0.9322775889 |
| GSE54402 | Down | -0.6213975918 |
| GSE9593 | Up | 0.1493299265 |
| GSE43922 | Down | -0.9333464528 |
| GSE24585 | Up | 0.8367425285 |
| GSE37065 | Down | -0.3506161505 |
| GSE28863_A1 | Up | 0.4747147108 |
| GSE28863_A2 | Down | -0.6609992504 |
| GSE28863_A3 | Down | -0.5315176556 |
| GSE28863_A4 | Up | 0.0771008515 |
| GSE48662 | Up | 0.2693855342 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| Guanidine | DB00536 | APRD01008 | EXPT01546 |
| Disulfiram | DB00822 | APRD00767 |
| Crotonaldehyde | DB04381 | EXPT01020 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016754 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1 | MIMAT0000416 | MIRT023536 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031438 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039939 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
