HCSGD entry for ALCAM
1. General information
| Official gene symbol | ALCAM |
|---|---|
| Entrez ID | 214 |
| Gene full name | activated leukocyte cell adhesion molecule |
| Other gene symbols | CD166 MEMD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005102 | Receptor binding | TAS | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008045 | Motor neuron axon guidance | IEA | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4628205007 | 0.0040583336 | 0.9999902473 | 0.1296351942 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6804372068 |
| GSE13712_SHEAR | Up | 0.7522845236 |
| GSE13712_STATIC | Up | 0.5178291712 |
| GSE19018 | Up | 0.4371234041 |
| GSE19899_A1 | Down | -1.6374110328 |
| GSE19899_A2 | Down | -1.1394440064 |
| PubMed_21979375_A1 | Down | -1.5731140249 |
| PubMed_21979375_A2 | Down | -1.8680380384 |
| GSE35957 | Down | -0.0305904013 |
| GSE36640 | Up | 0.5290384284 |
| GSE54402 | Down | -0.9907003740 |
| GSE9593 | Up | 0.1078978350 |
| GSE43922 | Down | -0.9210795738 |
| GSE24585 | Up | 0.4201456787 |
| GSE37065 | Up | 0.2861774145 |
| GSE28863_A1 | Down | -0.3861258189 |
| GSE28863_A2 | Down | -0.3413474034 |
| GSE28863_A3 | Down | -0.3801642659 |
| GSE28863_A4 | Down | -0.2689787749 |
| GSE48662 | Down | -0.0101572548 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT004163 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT004163 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024327 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20225285 | The expressions of CD166, CD49a, and CD106 decreased, whereas those of CD10, CD29, CD44, CD73, CD90, and CD105 showed no significant change |
| 20132052 | FACS analysis confirmed expression of the stem cell markers CD44, CD90, CD105, and CD166, but negative expression of CD34 and CD45 ruling out a hematopoietic or fibrocyte origin for these progenitors |
| 17371154 | Flow cytometric analysis indicated a strong need to investigate for novel cell-surface characteristic markers of BMSCs because there was no obvious difference in the expression of the selected characteristic BMSC cell surface markers CD29, CD44, CD90, CD105, and CD166 between fast-growing and slow-growing clones |
| 16229018 | There was a high expression of CD90, CD29, CD44 and CD105 and variable and moderate expression of CD166 and CD106 at the start of MSC culture and at each passage during expansion |
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