HCSGD entry for ETS1
1. General information
| Official gene symbol | ETS1 |
|---|---|
| Entrez ID | 2113 |
| Gene full name | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) |
| Other gene symbols | ETS-1 EWSR2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0003677 | DNA binding | ISS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA IMP | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007565 | Female pregnancy | IEA | biological_process |
| GO:0008134 | Transcription factor binding | NAS | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0009612 | Response to mechanical stimulus | IEA | biological_process |
| GO:0010595 | Positive regulation of endothelial cell migration | IMP | biological_process |
| GO:0010715 | Regulation of extracellular matrix disassembly | IEA | biological_process |
| GO:0021854 | Hypothalamus development | IEA | biological_process |
| GO:0021983 | Pituitary gland development | IEA | biological_process |
| GO:0030262 | Apoptotic nuclear changes | IDA | biological_process |
| GO:0030578 | PML body organization | IDA | biological_process |
| GO:0032355 | Response to estradiol | IEA | biological_process |
| GO:0034616 | Response to laminar fluid shear stress | IEA | biological_process |
| GO:0035035 | Histone acetyltransferase binding | IEA | molecular_function |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045648 | Positive regulation of erythrocyte differentiation | IDA | biological_process |
| GO:0045765 | Regulation of angiogenesis | IMP | biological_process |
| GO:0045766 | Positive regulation of angiogenesis | IEA | biological_process |
| GO:0045786 | Negative regulation of cell cycle | IDA IMP | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046677 | Response to antibiotic | IDA | biological_process |
| GO:0048870 | Cell motility | IMP | biological_process |
| GO:0051272 | Positive regulation of cellular component movement | IMP | biological_process |
| GO:0060055 | Angiogenesis involved in wound healing | IEA | biological_process |
| GO:0060206 | Estrous cycle phase | IEA | biological_process |
| GO:0070301 | Cellular response to hydrogen peroxide | IEA | biological_process |
| GO:0070555 | Response to interleukin-1 | IEA | biological_process |
| GO:0097194 | Execution phase of apoptosis | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0683986057 | 0.2696259793 | 0.5617222153 | 0.9928540355 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6178330617 |
| GSE13712_SHEAR | Up | 0.0744943777 |
| GSE13712_STATIC | Down | -0.1704661817 |
| GSE19018 | Down | -0.1329258681 |
| GSE19899_A1 | Up | 0.2710463138 |
| GSE19899_A2 | Up | 1.1106499153 |
| PubMed_21979375_A1 | Up | 1.5066591003 |
| PubMed_21979375_A2 | Up | 0.5237447469 |
| GSE35957 | Up | 0.3375842569 |
| GSE36640 | Down | -1.0962195825 |
| GSE54402 | Up | 0.6337060488 |
| GSE9593 | Down | -0.1885628078 |
| GSE43922 | Up | 0.2243424241 |
| GSE24585 | Down | -0.2782407652 |
| GSE37065 | Down | -0.2712405685 |
| GSE28863_A1 | Up | 0.1166710336 |
| GSE28863_A2 | Up | 0.0916602955 |
| GSE28863_A3 | Down | -0.0363785092 |
| GSE28863_A4 | Up | 0.1733564048 |
| GSE48662 | Down | -0.5019618865 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | MIRT006387 | Immunoblot//Luciferase reporter assay | Functional MTI | 21444677 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT000641 | Luciferase reporter assay | Non-Functional MTI | 19956200 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT000641 | Luciferase reporter assay | Functional MTI | 23383271 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT006064 | Luciferase reporter assay//qRT-PCR | Functional MTI | 23522449 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT003783 | Immunocytochemistry//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21081489 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT004975 | Luciferase reporter assay//qRT-PCR | Non-Functional MTI | 19524507 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT005104 | Microarray | Functional MTI (Weak) | 19193853 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT005104 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18950466 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT005104 | Reporter assay;Other | Functional MTI | 20584899 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT005104 | Reporter assay;Western blot;qRT-PCR | Functional MTI | 21310411 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT005516 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20655737 |
| hsa-miR-208a-3p | MIMAT0000241 | MIRT005541 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 20576608 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047624 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047908 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | 2 | hsa-miR-155 | 18950466 | |||
| hsa-miR-155-5p | MIMAT0000646 | 1 | hsa-miR-155 | 18950466 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 12 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26168478 | Conversely, the transcription factors Ets1/2 and histone H3K4 methyltransferase MLL1 directly bind to the p16 locus and mediate p16 induction during replicative and premature senescence |
| 25670864 | Ets-2, like its closely related homologue Ets-1, is a member of the Ets family of DNA binding transcription factors |
| 25670864 | One such regulatory mechanism is the presence of an autoinhibitory module, which in Ets-1 allosterically inhibits the DNA binding activity |
| 25670864 | The Ets domain crystallized with two distinct species in the asymmetric unit, which closely resemble the autoinhibited and DNA bound forms of Ets-1 |
| 25670864 | In contrast to Ets-1, in which the autoinhibition is caused by a combination of allosteric and steric mechanisms, we were unable to find clear evidence for the allosteric mechanism in Ets-2 |
| 25311168 | In addition, increased expression of CDKN2A and its transcriptional activators ETS1 and ARHGAP18 (SENEX) along with decreased expression of CDKN2A inhibitor ID1 were detected in FECD samples |
| 23872946 | Because ID proteins are negative regulators of the transcription factors ETS1/2, depletion of DPY30 leads to the transcriptional activation of p16INK4a by ETS1/2 and thus to a senescent-like phenotype |
| 22521293 | EMSA with supershift analysis for ETS1 and Mxi2 indicated the involvement of both factors in the protein-DNA interaction |
| 22521293 | After specifically blocking the endothelin receptors, ETS1 expression was significantly downregulated |
| 22521293 | SIGNIFICANCE: ETS1, ERK2 and Mxi2 are important complex partners initiating increased p16(INK4a) and p21w(af1/cip1) activation in renal tumor cells |
| 21843507 | Here, we show that ATRA induces promoter hypomethylation of p16 and p21 via down-regulation of DNA methyltransferases 1, 3a, and 3b to facilitate binding of Ets1/2 to the p16 promoter and p53 to the p21 promoter, resulting in up-regulation of their expression and subsequent induction of cellular senescence in HepG2 cells |
| 19907431 | When premature senescence was induced by specific exogenous stimuli, concomitant Ets-1 upregulation was also observed |
| 19656618 | HBx induced DNA hypermethylation of p16(INK4a) promoter and subsequently interfered action of transcription factors like Ets1 and Ets2 activated by H(2)O(2) through the p38(MAPK) pathway, resulting in inhibition of its transcription |
| 17026941 | This regulation involves p16INK4a transcriptional activators such as proteins Ets1 and 2 or E47 |
| 15659210 | Senescence was accompanied by a decline in transcript levels of the polycomb gene Bmi-1, Ets1 and Ets2 transcription factors, and Id1, Id2 and Id3 helix-loop-helix proteins, suggesting roles for these genes in maintenance of cardiomyocyte proliferative capacity |
| 15520862 | Last, the age-related increase in Ink4a/Arf expression can be independently attributed to the expression of Ets-1, a known p16INK4a transcriptional activator, as well as unknown Ink4a/Arf coregulatory molecules |
| 11234019 | Here we demonstrate a role for the Ets1 and Ets2 transcription factors based on their ability to activate the p16INK4a promoter through an ETS-binding site and their patterns of expression during the lifespan of human diploid fibroblasts |
| 11234019 | In senescent cells, where the Ets2 levels and MEK signalling decline, the marked increase in p16INK4a expression is consistent with the reciprocal reduction of Id1 and accumulation of Ets1 |
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