HCSGD entry for ESRRA
1. General information
| Official gene symbol | ESRRA |
|---|---|
| Entrez ID | 2101 |
| Gene full name | estrogen-related receptor alpha |
| Other gene symbols | ERR1 ERRa ERRalpha ESRL1 NR3B1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0004879 | Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | TAS | molecular_function |
| GO:0005496 | Steroid binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0030522 | Intracellular receptor signaling pathway | TAS | biological_process |
| GO:0042127 | Regulation of cell proliferation | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IDA IEA | molecular_function |
| GO:0045667 | Regulation of osteoblast differentiation | IEA | biological_process |
| GO:0045670 | Regulation of osteoclast differentiation | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA ISS | biological_process |
| GO:0051216 | Cartilage development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0322066525 | 0.8428744956 | 0.4142465071 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1547236060 |
| GSE13712_SHEAR | Up | 0.2226969247 |
| GSE13712_STATIC | Down | -0.0447754276 |
| GSE19018 | Down | -0.4699350963 |
| GSE19899_A1 | Up | 0.1037011064 |
| GSE19899_A2 | Up | 1.0822388891 |
| PubMed_21979375_A1 | Up | 1.1716732088 |
| PubMed_21979375_A2 | Up | 0.8438455662 |
| GSE35957 | Down | -0.1504090604 |
| GSE36640 | Up | 0.4816869683 |
| GSE54402 | Up | 0.4825925255 |
| GSE9593 | Down | -0.1028351117 |
| GSE43922 | Up | 0.5359546326 |
| GSE24585 | Down | -0.1433132433 |
| GSE37065 | Down | -0.1509338180 |
| GSE28863_A1 | Down | -0.3392932550 |
| GSE28863_A2 | Down | -0.0175515031 |
| GSE28863_A3 | Down | -0.0724188773 |
| GSE28863_A4 | Up | 0.3309114121 |
| GSE48662 | Up | 0.4429072232 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Troglitazone | DB00197 | APRD00488 |
| 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE | DB06833 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-137 | MIMAT0000429 | MIRT006957 | Luciferase reporter assay | Functional MTI | 22723937 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT016687 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020579 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028410 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039942 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
