HCSGD entry for ALAD
1. General information
| Official gene symbol | ALAD |
|---|---|
| Entrez ID | 210 |
| Gene full name | aminolevulinate dehydratase |
| Other gene symbols | ALADH PBGS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | TAS | molecular_function |
| GO:0004655 | Porphobilinogen synthase activity | IDA IEA TAS | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006778 | Porphyrin-containing compound metabolic process | TAS | biological_process |
| GO:0006779 | Porphyrin-containing compound biosynthetic process | IEA | biological_process |
| GO:0006782 | Protoporphyrinogen IX biosynthetic process | IEA | biological_process |
| GO:0006783 | Heme biosynthetic process | IDA TAS | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0032791 | Lead ion binding | IDA | molecular_function |
| GO:0033014 | Tetrapyrrole biosynthetic process | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051260 | Protein homooligomerization | IPI | biological_process |
| GO:0071353 | Cellular response to interleukin-4 | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4217374834 | 0.2988272596 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1038433858 |
| GSE13712_SHEAR | Up | 0.1073675859 |
| GSE13712_STATIC | Down | -0.3005069848 |
| GSE19018 | Up | 0.1528157592 |
| GSE19899_A1 | Down | -0.2048979814 |
| GSE19899_A2 | Down | -0.2362196218 |
| PubMed_21979375_A1 | Down | -1.2541934564 |
| PubMed_21979375_A2 | Down | -0.3958843183 |
| GSE35957 | Down | -0.0433427349 |
| GSE36640 | Up | 0.4960717616 |
| GSE54402 | Down | -0.3817374183 |
| GSE9593 | Up | 0.2713645706 |
| GSE43922 | Down | -0.0013223845 |
| GSE24585 | Up | 0.2014889352 |
| GSE37065 | Down | -0.0519527932 |
| GSE28863_A1 | Up | 0.5117926863 |
| GSE28863_A2 | Up | 0.5790468876 |
| GSE28863_A3 | Up | 0.1637242550 |
| GSE28863_A4 | Up | 0.0725489873 |
| GSE48662 | Down | -0.0429727196 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Aminolevulinic acid | DB00855 | APRD00793 | DB05277 |
| Delta-Amino Valeric Acid | DB02068 | EXPT01116 |
| Laevulinic Acid | DB02239 | EXPT02901 |
| 4-Oxosebacic Acid | DB02260 | EXPT00224 |
| Porphobilinogen | DB02272 | EXPT02507 |
| 3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic Acid | DB02878 | EXPT02503 |
| 4,7-Dioxosebacic Acid | DB04560 | EXPT01272 |
| 5-hydroxyvaleric acid | DB04781 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-142-3p | MIMAT0000434 | MIRT021588 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT050633 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
