HCSGD entry for ESR1
1. General information
| Official gene symbol | ESR1 |
|---|---|
| Entrez ID | 2099 |
| Gene full name | estrogen receptor 1 |
| Other gene symbols | ER ESR ESRA Era NR3A1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001046 | Core promoter sequence-specific DNA binding | IDA | molecular_function |
| GO:0001547 | Antral ovarian follicle growth | IEA | biological_process |
| GO:0002064 | Epithelial cell development | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA NAS | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA NAS TAS | molecular_function |
| GO:0004879 | Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | IEA | molecular_function |
| GO:0005496 | Steroid binding | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006338 | Chromatin remodeling | NAS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA TAS | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007200 | Phospholipase C-activating G-protein coupled receptor signaling pathway | ISS | biological_process |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | ISS | biological_process |
| GO:0008013 | Beta-catenin binding | IPI | molecular_function |
| GO:0008134 | Transcription factor binding | IEA | molecular_function |
| GO:0008209 | Androgen metabolic process | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008584 | Male gonad development | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010629 | Negative regulation of gene expression | IDA | biological_process |
| GO:0010863 | Positive regulation of phospholipase C activity | ISS | biological_process |
| GO:0016020 | Membrane | NAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030235 | Nitric-oxide synthase regulator activity | NAS | molecular_function |
| GO:0030284 | Estrogen receptor activity | IEA NAS | molecular_function |
| GO:0030518 | Intracellular steroid hormone receptor signaling pathway | ISS | biological_process |
| GO:0030520 | Intracellular estrogen receptor signaling pathway | NAS | biological_process |
| GO:0032355 | Response to estradiol | IDA | biological_process |
| GO:0034056 | Estrogen response element binding | IDA | molecular_function |
| GO:0038052 | Estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | IGI | molecular_function |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042981 | Regulation of apoptotic process | IEA | biological_process |
| GO:0043124 | Negative regulation of I-kappaB kinase/NF-kappaB signaling | IDA | biological_process |
| GO:0043433 | Negative regulation of sequence-specific DNA binding transcription factor activity | IDA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0043627 | Response to estrogen | IDA | biological_process |
| GO:0045429 | Positive regulation of nitric oxide biosynthetic process | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IEA | biological_process |
| GO:0048146 | Positive regulation of fibroblast proliferation | IEA | biological_process |
| GO:0048386 | Positive regulation of retinoic acid receptor signaling pathway | IDA | biological_process |
| GO:0051000 | Positive regulation of nitric-oxide synthase activity | IDA | biological_process |
| GO:0051091 | Positive regulation of sequence-specific DNA binding transcription factor activity | IDA | biological_process |
| GO:0060065 | Uterus development | IEA | biological_process |
| GO:0060068 | Vagina development | IEA | biological_process |
| GO:0060523 | Prostate epithelial cord elongation | IEA | biological_process |
| GO:0060527 | Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis | IEA | biological_process |
| GO:0060687 | Regulation of branching involved in prostate gland morphogenesis | IEA | biological_process |
| GO:0060745 | Mammary gland branching involved in pregnancy | IEA | biological_process |
| GO:0060749 | Mammary gland alveolus development | IEA | biological_process |
| GO:0060750 | Epithelial cell proliferation involved in mammary gland duct elongation | IEA | biological_process |
| GO:0071391 | Cellular response to estrogen stimulus | IEA | biological_process |
| GO:0071392 | Cellular response to estradiol stimulus | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5832440371 | 0.9424623077 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0045825063 |
| GSE13712_SHEAR | Down | -0.0350583821 |
| GSE13712_STATIC | Up | 0.0078055677 |
| GSE19018 | Up | 0.1754637308 |
| GSE19899_A1 | Up | 0.0475094470 |
| GSE19899_A2 | Up | 0.1735936491 |
| PubMed_21979375_A1 | Down | -0.0279305065 |
| PubMed_21979375_A2 | Down | -0.0607604409 |
| GSE35957 | Down | -0.0448622602 |
| GSE36640 | Up | 0.0652552028 |
| GSE54402 | Up | 0.0131762407 |
| GSE9593 | Down | -0.0206022082 |
| GSE43922 | Up | 0.0722974000 |
| GSE24585 | Up | 0.1318169847 |
| GSE37065 | Up | 0.0542235261 |
| GSE28863_A1 | Up | 0.1898588659 |
| GSE28863_A2 | Up | 0.2944533088 |
| GSE28863_A3 | Up | 0.1340120932 |
| GSE28863_A4 | Down | -0.0911624591 |
| GSE48662 | Down | -0.0152026385 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26a-5p | MIMAT0000082 | MIRT006389 | Luciferase reporter assay | Functional MTI | 21610700 |
| hsa-miR-302c-3p | MIMAT0000717 | MIRT000699 | Luciferase reporter assay//Microarray | Functional MTI | 19684618 |
| hsa-miR-206 | MIMAT0000462 | MIRT000700 | Luciferase reporter assay//qRT-PCR//Western blot//Western blot;qRT-PCR | Functional MTI | 17312270 |
| hsa-miR-206 | MIMAT0000462 | MIRT000700 | Luciferase reporter assay//Microarray | Functional MTI | 19684618 |
| hsa-miR-206 | MIMAT0000462 | MIRT000700 | Immunoblot//Luciferase reporter assay//qRT-PCR | Non-Functional MTI | 19414598 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT000701 | Luciferase reporter assay//Microarray | Functional MTI | 19684618 |
| hsa-miR-18b-5p | MIMAT0001412 | MIRT000702 | Luciferase reporter assay//Microarray | Functional MTI | 19684618 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT000703 | Western blot//qRT-PCR//Luciferase reporter assay | Functional MTI | 19706389 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT000703 | Luciferase reporter assay//Microarray | Functional MTI | 19684618 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT000703 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20080637 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT002474 | Western blot | Functional MTI | 18347104 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT002474 | Luciferase reporter assay//Immunoblot//qRT-PCR | Functional MTI | 19414598 |
| hsa-miR-19a-3p | MIMAT0000073 | MIRT003214 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20080637 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT004308 | Western blot | Functional MTI | 19706389 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT004309 | Western blot//qRT-PCR//Luciferase reporter assay | Functional MTI | 19706389 |
| hsa-miR-20b-5p | MIMAT0001413 | MIRT004313 | Western blot//qRT-PCR//Luciferase reporter assay | Functional MTI | 19706389 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT005320 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18790736 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT005321 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18790736 |
| hsa-miR-130a-3p | MIMAT0000425 | MIRT006356 | GFP reporter assay | Functional MTI | 21712254 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-22-3p | MIMAT0000077 | NA | hsa-miR-22 | {Western blot} | {underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 18347104 | |
| hsa-miR-206 | MIMAT0000462 | 2 | hsa-miR-206 | {Western blot} | {overexpression by miRNA precursor transfection} | 17312270 | |
| hsa-miR-206 | MIMAT0000462 | 1 | hsa-miR-206 | {Western blot} | {overexpression by miRNA precursor transfection} | 17312270 | |
| hsa-miR-222-3p | MIMAT0000279 | 1 | hsa-miR-222 | {Western blot} | {overexpression} | 18790736 | |
| hsa-miR-221-3p | MIMAT0000278 | 1 | hsa-miR-221 | {Western blot} | {overexpression} | 18790736 | |
| hsa-miR-22-3p | MIMAT0000077 | NA | hsa-miR-22 | {Western blot} | {overexpression} | 20180843 | |
| hsa-miR-19a-3p | MIMAT0000073 | NA | hsa-miR-19a | {Western blot} | {overexpression by miRNA precursor transfection} | 20080637 | |
| hsa-miR-19b-3p | MIMAT0000074 | NA | hsa-miR-19b | {Luciferase activity assay} | {downregulation by anti-miRNA oligonucleotide} | {luciferase} | 19706389 |
| hsa-miR-20b-5p | MIMAT0001413 | NA | hsa-miR-20b | {Luciferase activity assay} | {downregulation by anti-miRNA oligonucleotide} | {luciferase} | 19706389 |
| hsa-miR-181a-5p | MIMAT0000256 | 1 | hsa-miR-181a | 19684618 | |||
| hsa-miR-181a-5p | MIMAT0000256 | 2 | hsa-miR-181a | 19684618 | |||
| hsa-miR-181a-5p | MIMAT0000256 | 3 | hsa-miR-181a | 19684618 | |||
| hsa-miR-181b-5p | MIMAT0000257 | 1 | hsa-miR-181b | 19684618 | |||
| hsa-miR-181b-5p | MIMAT0000257 | 2 | hsa-miR-181b | 19684618 | |||
| hsa-miR-181b-5p | MIMAT0000257 | 3 | hsa-miR-181b | 19684618 | |||
| hsa-miR-193b-3p | MIMAT0002819 | 1 | hsa-miR-193b | 19684618 | |||
| hsa-miR-206 | MIMAT0000462 | 2 | hsa-miR-206 | 19684618 | |||
| hsa-miR-206 | MIMAT0000462 | 4 | hsa-miR-206 | 19684618 | |||
| hsa-miR-206 | MIMAT0000462 | 1 | hsa-miR-206 | 19684618 | |||
| hsa-miR-206 | MIMAT0000462 | 3 | hsa-miR-206 | 19684618 | |||
| hsa-miR-302c-3p | MIMAT0000717 | 2 | hsa-miR-302c | 19684618 | |||
| hsa-miR-302c-3p | MIMAT0000717 | 1 | hsa-miR-302c | 19684618 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 19 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27259243 | Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells |
| 27259243 | We aimed to elucidate the role of estrogen receptor alpha (ERalpha) on senescence in transformed human mammary epithelial cells and breast cancer cells |
| 26240345 | We developed a mouse model, Tg(KRT14-cre/Esr1) (20Efu/J) x Sod2 (tm1Smel) , that generates mitochondrial oxidative stress in keratin 14-expressing epidermal stem/progenitor cells in a temporally controlled manner owing to deletion of Sod2, a nuclear gene that encodes the mitochondrial antioxidant enzyme superoxide dismutase 2 (Sod2) |
| 24885022 | Estrogen receptor alpha and aryl hydrocarbon receptor independent growth inhibitory effects of aminoflavone in breast cancer cells |
| 24885022 | BACKGROUND: Numerous studies have implicated the aryl hydrocarbon receptor (AhR) as a potential therapeutic target for several human diseases, including estrogen receptor alpha (ERalpha) positive breast cancer |
| 24448819 | To further investigate the role of dovitinib, we analyzed its effect on estrogen receptor alpha (ER-alpha) expression |
| 24112790 | Furthermore, in kisspeptin neurons, the expression of estrogen receptor alpha (ERalpha), but not progesterone receptor (PR), decreased with age |
| 21671470 | Estrogen repression of YPEL3 expression was found to be independent of p53 but dependent on estrogen receptor alpha expression |
| 21613412 | Endocrine therapies that target estrogen receptor alpha (ERalpha) action (tamoxifen, toremifene, fulvestrant) or estrogen synthesis (aromatase inhibitors: letrozole, anastrozole, exemestane; or ovarian suppression) are a clinical mainstay |
| 19479343 | Nitrones can act as spin traps to detect, identify, quantify and locate the radicals responsible using electron paramagnetic resonance (EPR or ESR) spectroscopy, and a new carnitine-derived nitrone, CarnDOD-7C, designed to accumulate in mitochondria is reported |
| 19023015 | Of interest, both estrogen and NO signaling, specifically through the estrogen receptor-alpha (ERalpha) and the endothelial isoform of the nitric oxide synthase (eNOS), have been shown to counteract endothelial senescence through a shared downstream effector, the catalytic subunit of human telomerase (hTERT), a key molecule in the aging process |
| 18847333 | Using bone from cycling female rats infused chronically with ethanol (EtOH) in vivo and osteoblastic cells in vitro, we found that EtOH significantly increased estrogen receptor alpha (ERalpha) and beta (ERbeta) mRNA and ERalpha protein levels |
| 15531092 | A subcellular distribution of estrogen receptor-alpha is changed during artificially induced senescence of PC12 pheochromocytoma cells |
| 14718559 | We observed a much more extensive generalized stress response known as the environmental stress response (ESR), than observed previously in biotin-streptavidin-isolated cells, perhaps because the elutriated cells were further advanced in their life span |
| 12135889 | Telomerase-expressing cells contained mRNA for alpha smooth muscle actin, smoothelin, oxytocin receptor, and estrogen receptor alpha, but the estrogen receptor beta receptor was lost |
| 11781307 | Contribution of estrogen receptor alpha to oncogenic K-Ras-mediated NIH3T3 cell transformation and its implication for escape from senescence by modulating the p53 pathway |
| 11781307 | We previously reported that enhanced transcriptional activation of estrogen receptor alpha (ERalpha) contributed to [(12)Val]K-Ras-mediated NIH3T3 cell transformation |
| 2659087 | The action of endogenous membrane proteinases in membranes isolated from human red cells of various ages was assayed by three groups of methods: (1) determination of the amount of protein fragments released to the acid-soluble fraction; (2) monitoring of changes in ESR spectra of maleimide spin-labeled erythrocyte membranes; (3) electrophoretic methods: a two-dimensional analysis and analysis of the activity inside SDS-PAGE gels |
| 2538381 | ESR spectroscopy has been used to investigate the formation of paramagnetic species during the development of internal rust spot (IRS) in the potato tuber |
| 3038172 | At low temperatures, a fraction of the labels gave rise to a strongly immobilized ESR component |
| 6279195 | A method is proposed for the determination of nitroxide-reducing capacity (NRC) of erythrocytes, and other cells, based on measurements of reduction of a nitroxide stable free radical in cell suspensions by ESR spectroscopy |
| 6266465 | ESR spectra of membrane-bound maleimide spin label evidenced alterations in the state of membrane proteins during cell aging in vivo |
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