HCSGD entry for FBL
1. General information
| Official gene symbol | FBL |
|---|---|
| Entrez ID | 2091 |
| Gene full name | fibrillarin |
| Other gene symbols | FIB FLRN RNU3IP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001652 | Granular component | IEA | cellular_component |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006364 | RRNA processing | IEA | biological_process |
| GO:0008033 | TRNA processing | IEA | biological_process |
| GO:0008168 | Methyltransferase activity | IEA | molecular_function |
| GO:0015030 | Cajal body | IDA IEA | cellular_component |
| GO:0016074 | SnoRNA metabolic process | IEA | biological_process |
| GO:0031428 | Box C/D snoRNP complex | NAS | cellular_component |
| GO:1990258 | Histone glutamine methylation | IDA | biological_process |
| GO:1990259 | Histone-glutamine methyltransferase activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9945700467 | 0.0012338589 | 0.9999902473 | 0.0668238683 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7815078660 |
| GSE13712_SHEAR | Down | -0.5573680330 |
| GSE13712_STATIC | Down | -0.3461097317 |
| GSE19018 | Down | -0.3372090329 |
| GSE19899_A1 | Down | -0.4299403529 |
| GSE19899_A2 | Down | -0.6046200662 |
| PubMed_21979375_A1 | Down | -0.2653694274 |
| PubMed_21979375_A2 | Down | -0.7764129854 |
| GSE35957 | Down | -1.2172656244 |
| GSE36640 | Down | -2.2276229816 |
| GSE54402 | Up | 0.3091126491 |
| GSE9593 | Down | -0.8949379852 |
| GSE43922 | Down | -0.1192172778 |
| GSE24585 | Down | -0.5202440659 |
| GSE37065 | Down | -0.4810306328 |
| GSE28863_A1 | Up | 0.0723496861 |
| GSE28863_A2 | Down | -0.5865369446 |
| GSE28863_A3 | Down | -0.2639879884 |
| GSE28863_A4 | Up | 0.2902430051 |
| GSE48662 | Down | -0.5766556785 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-324-5p | MIMAT0000761 | MIRT043089 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047276 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050515 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17624691 | Co-localization with a nucleolar protein, fibrillarin, showed that rPinX1 resides in the nucleolus |
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