HCSGD entry for ERN1

1. General information

Official gene symbolERN1
Entrez ID2081
Gene full nameendoplasmic reticulum to nucleus signaling 1
Other gene symbolsIRE1 IRE1P IRE1a hIRE1p
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0004521Endoribonuclease activityIDA TASmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005637Nuclear inner membraneIEAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseIDA TASbiological_process
GO:0007050Cell cycle arrestISSbiological_process
GO:0030176Integral component of endoplasmic reticulum membraneIDAcellular_component
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0046777Protein autophosphorylationIEAbiological_process
GO:0070055HAC1-type intron splice site recognition and cleavageIDAbiological_process
GO:0070059Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIEAbiological_process
GO:0090305Nucleic acid phosphodiester bond hydrolysisIDA TASbiological_process
GO:0090501RNA phosphodiester bond hydrolysisIDA TASbiological_process
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolyticIDA TASbiological_process
GO:1900103Positive regulation of endoplasmic reticulum unfolded protein responseIMPbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00080221120.99730532650.07933595511.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2339620638
GSE13712_SHEARUp0.8095004127
GSE13712_STATICUp0.7074278460
GSE19018Down-0.2734874660
GSE19899_A1Up0.6323566882
GSE19899_A2Up1.8307732371
PubMed_21979375_A1Up2.0433189778
PubMed_21979375_A2Up1.6710088577
GSE35957Up0.0078960291
GSE36640Up0.8085590423
GSE54402Up0.7528711247
GSE9593Up0.3800349718
GSE43922Up0.8442161662
GSE24585Up0.1725364184
GSE37065Up0.2796866528
GSE28863_A1Up0.4968823035
GSE28863_A2Up0.4196375551
GSE28863_A3Up0.0612151294
GSE28863_A4Down-0.0168320021
GSE48662Up0.0853573006

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1287853CHEMBL11631019O75460
CHEMBL535CHEMBL11631019O75460
CHEMBL572878CHEMBL11631019O75460
CHEMBL1721885CHEMBL11631019O75460
CHEMBL574738CHEMBL11631019O75460
CHEMBL162CHEMBL11631019O75460
CHEMBL1908395CHEMBL11631019O75460
CHEMBL491473CHEMBL11631019O75460
CHEMBL509032CHEMBL11631019O75460
CHEMBL1908392CHEMBL11631019O75460
CHEMBL608533CHEMBL11631019O75460
CHEMBL475251CHEMBL11631019O75460
CHEMBL1789941CHEMBL11631019O75460
CHEMBL249697CHEMBL11631019O75460
CHEMBL1908397CHEMBL11631019O75460
CHEMBL603469CHEMBL11631019O75460
CHEMBL608533CHEMBL11631018O75460
CHEMBL535CHEMBL11631018O75460
CHEMBL603469CHEMBL11631018O75460
Entries Per Page
Displaying Page of

  • Drugs

Name

Drug

Accession number

N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamineDB07382 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7a-5pMIMAT0000062MIRT052484CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25149687Results show that in replicative senescence and CuSO4-SIPS, immunoglobulin binding protein, calnexin, protein disulfide isomerase, and ER oxireductin-1 levels adjust to restore proteostasis and inositol-requiring enzyme-1 (IRE1)-, activating transcription factor 6 (ATF6)-, and pancreatic ER kinase (PERK)-mediated unfolded protein response are activated
25149687However, H2O2-SIPS does not exhibit IRE1 and ATF6 pathways activation but a PERK-mediated upregulation of CCAAT/enhancer-binding protein homologous protein, showing that CuSO4-SIPS mimics better the endoplasmic reticulum molecular events of replicative senescence than H2O2-SIPS
25149687Moreover, unfolded protein response activation is required for both SIPS models induction, because PERK and IRE1 inhibitors decreased senescence-associated beta-galactosidase appearance
22548801Interestingly, the depletion of PERK but not ATF6 and IRE1 also induces cellular senescence, which was rescued by additional depletion of Akt
Entries Per Page
Displaying Page of