HCSGD entry for ERCC6

1. General information

Official gene symbol	ERCC6
Entrez ID	2074
Gene full name	excision repair cross-complementing rodent repair deficiency, complementation group 6
Other gene symbols	ARMD5 CKN2 COFS COFS1 CSB RAD26 UVSS1
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000303	Response to superoxide	IEA	biological_process
GO:0003677	DNA binding	IDA IEA	molecular_function
GO:0003678	DNA helicase activity	IDA	molecular_function
GO:0003682	Chromatin binding	IDA	molecular_function
GO:0004386	Helicase activity	IEA	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005524	ATP binding	IDA IEA	molecular_function
GO:0005634	Nucleus	IDA	cellular_component
GO:0005654	Nucleoplasm	IDA TAS	cellular_component
GO:0005730	Nucleolus	IDA	cellular_component
GO:0006200	ATP catabolic process	IDA	biological_process
GO:0006281	DNA repair	TAS	biological_process
GO:0006283	Transcription-coupled nucleotide-excision repair	IEA IMP TAS	biological_process
GO:0006284	Base-excision repair	IMP	biological_process
GO:0006289	Nucleotide-excision repair	TAS	biological_process
GO:0006290	Pyrimidine dimer repair	IEA	biological_process
GO:0006366	Transcription from RNA polymerase II promoter	NAS	biological_process
GO:0006979	Response to oxidative stress	IDA	biological_process
GO:0007256	Activation of JNKK activity	IEA	biological_process
GO:0007257	Activation of JUN kinase activity	IEA	biological_process
GO:0008022	Protein C-terminus binding	IPI	molecular_function
GO:0008023	Transcription elongation factor complex	IDA	cellular_component
GO:0008094	DNA-dependent ATPase activity	IDA	molecular_function
GO:0008630	Intrinsic apoptotic signaling pathway in response to DNA damage	IEA	biological_process
GO:0009411	Response to UV	IDA	biological_process
GO:0009636	Response to toxic substance	IEA	biological_process
GO:0010165	Response to X-ray	IEA	biological_process
GO:0010224	Response to UV-B	IEA	biological_process
GO:0010332	Response to gamma radiation	IEA	biological_process
GO:0032403	Protein complex binding	IDA	molecular_function
GO:0032784	Regulation of DNA-templated transcription, elongation	IDA	biological_process
GO:0032786	Positive regulation of DNA-templated transcription, elongation	IDA	biological_process
GO:0035264	Multicellular organism growth	IEA	biological_process
GO:0045494	Photoreceptor cell maintenance	IEA	biological_process
GO:0047485	Protein N-terminus binding	IPI	molecular_function

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.0084897420	0.7894764865	0.2370178270	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.1165063669
GSE13712_SHEAR	Up	0.3321719870
GSE13712_STATIC	Down	-0.1096696907
GSE19018	Up	0.2001248886
GSE19899_A1	Up	0.0569480023
GSE19899_A2	Up	0.9091276633
PubMed_21979375_A1	Up	0.3499401198
PubMed_21979375_A2	Up	0.2612609827
GSE35957	Up	0.0679785509
GSE36640	Up	1.1132836438
GSE54402	Up	0.1352851133
GSE9593	Up	0.0622222889
GSE43922	-	-
GSE24585	-	-
GSE37065	-	-
GSE28863_A1	Up	1.1522557428
GSE28863_A2	Up	1.3004318522
GSE28863_A3	Down	-1.1331917506
GSE28863_A4	Up	0.3747297990
GSE48662	Up	0.1049146217

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results