HCSGD entry for ERCC5

1. General information

Official gene symbolERCC5
Entrez ID2073
Gene full nameexcision repair cross-complementing rodent repair deficiency, complementation group 5
Other gene symbolsCOFS3 ERCM2 UVDR XPG XPGC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000405Bubble DNA bindingIDAmolecular_function
GO:0000718Nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0000737DNA catabolic process, endonucleolyticIDAbiological_process
GO:0003690Double-stranded DNA bindingIDAmolecular_function
GO:0003697Single-stranded DNA bindingIDA IEAmolecular_function
GO:0004519Endonuclease activityIEA TASmolecular_function
GO:0004520Endodeoxyribonuclease activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005675Holo TFIIH complexIDAcellular_component
GO:0006281DNA repairTASbiological_process
GO:0006283Transcription-coupled nucleotide-excision repairIMP TASbiological_process
GO:0006289Nucleotide-excision repairIEA TASbiological_process
GO:0006295Nucleotide-excision repair, DNA incision, 3'-to lesionIDA IMPbiological_process
GO:0008340Determination of adult lifespanIEAbiological_process
GO:0009411Response to UVIDA IMPbiological_process
GO:0009650UV protectionIGIbiological_process
GO:0010225Response to UV-CIMPbiological_process
GO:0016591DNA-directed RNA polymerase II, holoenzymeIDAcellular_component
GO:0035264Multicellular organism growthIEAbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0047485Protein N-terminus bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00765171540.99685969760.22806951631.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.8440152332
GSE13712_SHEARDown-0.0568763604
GSE13712_STATICDown-0.0513456183
GSE19018Up0.3503408428
GSE19899_A1Up0.6889982819
GSE19899_A2Up0.5542616451
PubMed_21979375_A1Up0.4402000335
PubMed_21979375_A2Up1.1932271064
GSE35957Up0.3315775404
GSE36640Up0.8699164038
GSE54402Up0.4795976794
GSE9593Down-0.0979215509
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.0444269680

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022203MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

10022922The xeroderma pigmentosum group G (XP-G) gene (XPG) encodes a structure-specific DNA endonuclease that functions in nucleotide excision repair (NER)
10022922XP-G patients show various symptoms, ranging from mild cutaneous abnormalities to severe dermatological impairments
10022922The known XPG protein function as the 3' nuclease in NER, however, cannot explain the development of CS in certain XP-G patients
10022922To gain an insight into the functions of the XPG protein, we have generated and examined mice lacking xpg (the mouse counterpart of the human XPG gene) alleles
10022922Since XPA-deficient mice, which are totally defective in NER, do not show such symptoms, our data indicate that XPG performs an additional function(s) besides its role in NER
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